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首页> 外文期刊>Endocrine journal >Quantitative Insulin Sensitivity Check Index Is a Useful Indicator of Insulin Resistance in Japanese Metabolically Obese, Normal-Weight Subjects with Normal Glucose Tolerance
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Quantitative Insulin Sensitivity Check Index Is a Useful Indicator of Insulin Resistance in Japanese Metabolically Obese, Normal-Weight Subjects with Normal Glucose Tolerance

机译：定量胰岛素敏感性检查指数是日本代谢性肥胖，体重正常，糖耐量正常的胰岛素抵抗的有用指标

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摘要

To clarify whether quantitative insulin sensitivity check index (QUICKI) is useful as an indicator of insulin resistance in Japanese metabolically obese, normal-weight (MONW, body mass index (BMI) < 25 and visceral fat area (VFA) ≥ 100 cm~2 by abdominal computed tomography scanning) subjects with normal glucose tolerance (NGT). Insulin resistance was measured by QUICKI and euglycemic hyperinsulinemic clamp study (clamp IR) in 27 MONW and 27 normal subjects (BMI < 25 and visceral fat area < 100 cm~2). QUICKI (P < 0.01) and clamp IR (p < 0.01) were significantly decreased in MONW subjects compared with normal subjects. QUICKI was significantly associated with VFA [MONW subjects: r =-0.459, p < 0.02; all (MONW and normal) subjects: r =-0.506, p < 0.0001] and with the serum levels of triglycerides (MONW subjects: r = -0.386, p < 0.05; all subjects: r = -0.505, p < 0.001) in MONW and all subjects. There were significant correlations between clamp IR and VFA (MONW subjects: r =-0.562, p < 0.01; all subjects: r =-0.575, p < 0.0001), fasting serum levels of insulin (MONW subjects: r = -0.673, p < 0.001 ; all subjects: r =-0.619, p < 0.0001)or serum levels of triglycerides (MONW subjects: r = -0.485, p < 0.02; all subjects: r = -0.565, p < 0.0001) in MONW and all subjects. QUICKI was significantly correlated with clamp IR in MONW (r = 0.754, p < 0.0001) and in all subjects (r = 0.568, p < 0.0001). QUICKI may be an useful method for assessing insulin resistance in Japanese MONW subjects with NGT.
机译：为了阐明定量胰岛素敏感性检查指数（QUICKI）是否可作为日本代谢性肥胖，正常体重（MONW，体重指数（BMI）<25）和内脏脂肪区（VFA）≥100 cm〜2的胰岛素抵抗的指标通过腹部计算机断层扫描）具有正常葡萄糖耐量（NGT）的受试者。通过QUICKI和正常血糖高胰岛素钳夹研究（钳夹IR）测量了27例MONW和27例正常受试者（BMI <25和内脏脂肪面积<100 cm〜2）的胰岛素抵抗。与正常受试者相比，MONW受试者的QUICKI（P <0.01）和钳夹IR（p <0.01）显着降低。 QUICKI与VFA显着相关[MONW受试者：r = -0.459，p <0.02；所有（MONW和正常）受试者：r = -0.506，p <0.0001]，并伴有甘油三酸酯的血清水平（MONW受试者：r = -0.386，p <0.05；所有受试者：r = -0.505，p <0.001） MONW和所有主题。钳制IR和VFA之间存在显着相关性（MONW受试者：r = -0.562，p <0.01；所有受试者：r = -0.575，p <0.0001），空腹胰岛素水平（MONW受试者：r = -0.673，p <0.001；所有受试者：r = -0.619，p <0.0001）或MONW和所有受试者的甘油三酸酯血清水平（MONW受试者：r = -0.485，p <0.02；所有受试者：r = -0.565，p <0.0001） 。 QUICKI与MONW（r = 0.754，p <0.0001）和所有受试者（r = 0.568，p <0.0001）的钳夹IR显着相关。 QUICKI可能是评估NGT日本MONW患者胰岛素抵抗的有用方法。

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