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首页> 外文期刊>Infection and immunity >In Vivo Behavior of Revertants from Staphylococcus aureus L-Phase Variants Compared with the Parent Strain
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In Vivo Behavior of Revertants from Staphylococcus aureus L-Phase Variants Compared with the Parent Strain

机译：与母体菌株相比，葡萄球菌L相变体的倒退剂的体内行为

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The in vivo behavior of revertants of Staphylococcus aureus L-phase variants were studied in mice. The Giorgio strain of S. aureus was induced into L-phase variants by methicillin. After 13 serial passages in methicillin agar and six passages in antibiotic-free agar, reversion occurred. Six revertants, all phage untypable, coagulase negative, and mannitol negative, were inoculated intravenously into Swiss albino mice in comparison with the parent strain. Inoculation of 108 colony-forming units resulted in 38% mortality at 28 days for the Giorgio group and 0 to 2% for the revertants. The geometric mean titer of staphylococci in the kidneys was 3.5 × 105 for the Giorgio group and 0.5 × 100 to 1.0 × 102 for the revertants. Serial colony counts of blood, lungs, spleen, liver, and kidneys in mice inoculated with 107 colony-forming units showed faster clearance and failure of the revertant to colonize the kidneys. It is concluded that the in vivo behavior of the L-phase revertants was vastly different from that of the parent Giorgio strain.
机译：在小鼠中研究了金黄色葡萄球菌的倒退剂的体内行为。 S的痛苦应变。 AUREUS 被甲氧西林诱导为L相变体。在13例甲氧嘧啶琼脂中串行通道和六个通道在无抗生素琼脂中，发生逆转。与亲本菌株相比，六个回复剂，所有噬菌体，凝血酶阴性和甘露醇阴性静脉内接种到瑞士白化小鼠中。接种10 8 菌落形成单位导致Giorgio组28天的死亡率为38％，回复剂的0〜2％。肾脏中的葡萄球菌的几何平均滴度为姜基基团的3.5×10 5 ，0.5×10 0 至1.0×10 2 回归者。血液，肺，脾，肝脏和肾脏的串行菌落计数接种10个 7 菌落形成单元的菌落形成单元显示出更快的间隙和失效，以使肾脏定植。结论是，L相回物的体内行为与母体Giorgio菌株的体内行为大不相同。

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