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首页> 外文期刊>Infection and immunity >Rabies virus immunity in genetically selected high- and low-responder lines of mice.
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Rabies virus immunity in genetically selected high- and low-responder lines of mice.

机译：狂犬病病毒免疫在遗传上选择的高响应者小鼠。

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The antibody responsiveness to and the specific vaccination effect of rabies virus infection were investigated in high- and low-responder lines of mice produced by two-way selective breedings for quantitative production of antibodies to flagellar (H/f and L/f lines) or somatic (H/s and L/s lines) antigens of salmonellae. After specific immunization, both high lines were more resistant to rabies virus infection than were the low lines, and the protector effect was related to the level of antibody produced, as demonstrated by neutralizing serum activity. The present findings confirm the nonspecific genetic modification of the general antibody responsiveness induced in high- and low-responder lines selected for quantitative antibody production.
机译：在通过双向选择性繁殖的高响应者患者中研究了狂犬病病毒感染的抗体对狂犬病病毒感染的抗体反应性和特异性疫苗接种效应，用于定量生产抗鞭毛（H / F和L / F线）或Somatic（H / S和L / S线）抗原的Salmonellae。经过具体的免疫后，两条高线对狂犬病病毒感染更耐受低线，并且保护器效应与通过中和血清活性所证明的抗体的水平有关。本研究结果证实了在为定量抗体生产中选择的高和低响应器线中诱导的一般抗体反应性的非特异性遗传修饰。

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