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首页> 外文期刊>Molecular and Cellular Biology >Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site.
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Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site.

机译：γ-干扰素诱导基因（IP-10）的基因组特征及其鉴定干扰素诱导的过敏位点。

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The genomic organization of a gamma-interferon-inducible gene, IP-10, reveals three introns that interrupt the transcribed sequence into four functional domains. Comparison of the intron-exon structure of this gene to the gene for an homologous chemotactic platelet protein, platelet factor 4, establishes that both genes are interrupted in precisely the same positions within homologous codons; this demonstrates that they belong to a gene family that evolved from a common ancestor. IP-10 and PF4 are two members of a newly described gene family that is likely to include the homologous chemotactic and mitogenic platelet basic proteins (connective tissue-activating protein III and beta-thromboglobulin), the transformation-related protein 9E3, and 310c, a mitogen-stimulated leukocyte protein. A DNase I-hypersensitive site has been found in responsive cells in a region upstream of the RNA initiation site. This hypersensitive site is induced by gamma interferon and thus provides a structural basis for the transcriptional activation seen for this gene by gamma interferon.
机译：γ-干扰素诱导基因IP-10的基因组组织揭示了将转录序列中断到四个功能域中的三个内含子。将该基因的内外区结构与同源趋化血小板蛋白，血小板因子4的基因的比较确定，两种基因在同源密码子内精确地中断;这表明它们属于一种从共同的祖先演变的基因家族。 IP-10和PF4是新描述的基因家族的两个成员，其可能包括同源趋化和促毒性血小板碱性蛋白质（结缔组织活化蛋白III和β-血小板球蛋白），转化相关蛋白质9e3和310℃，促丝胶刺激的白细胞蛋白。已在RNA引发位点上游的区域中的响应细胞中发现了DNase I-过度敏感性位点。该过敏位点由γ干扰素诱导，从而为通过γ干扰素达到该基因的转录激活提供了结构依据。

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