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首页> 外文期刊>Environment international >Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage
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Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage

机译：收银员在皮肤上接触双酚A的程度更高，并且与DNA氧化损伤有关

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摘要

Bisphenol A (BPA) is a widely used chemical in the production of many polycarbonate plastics, epoxy resin linings for food and beverage containers and thermal papers. Oral intakes from the contaminated diets were considered as the predominant source of BPA exposure for humans. However, due to the high levels of BPA on thermal receipts and their wide applications in our daily life, the amount of BPA be transferred to the skin after holding thermal paper should not be underestimated, particularly for cashiers. To investigate the contribution of BPA exposure levels via the dermal contact route and the relationship between BPA exposure level and oxidative DNA damage, six male volunteers were recruited and required to simulate the cashiers' work and handle the thermal receipts during the study period. Triclosan (TCS, an antimicrobial compound used widely in personal health and skin care products) was applied as a reference compound. Their urinary BPA, TCS and 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations were determined by high performance liquid chromatography/tandem spectrometer (LC/MS/MS). The results showed that after handling the thermal receipts, the urinary BPA concentrations of volunteers increased 3 times of those before the experimental period. But TCS levels in urine kept stable. There existed a correlation between BPA exposure and 8-OHdG (R-2 = 0.237, p < 0.001), but not between TCS and 8-OHdG concentrations (R-2 = 0.026, p < 0.777), indicating that more BPA exposure could lead to higher oxidative DNA damage. That the increases in 8-OHdG levels in urine being almost consistent with those of BPA suggested that handling thermal receipts resulted in the increasing BPA intakes and BPA exposure was correlated with DNA oxidative damage. After 48 h of the end of handling thermal receipts, the urinary BPA levels did not descend to the levels before experiment, suggesting that the excretion of BPA via dermal contact was over 48 h. BPA exposure through dermal contact route contributed 51.9% to 84% to urinary BPA levels with the GMratio of 70.9% for cashiers, indicating that it might be seriously underestimated for cashiers according to the previous studies. More attentions should be paid on the exposure of BPA via dermal penetration for cashiers. (C) 2016 Elsevier Ltd. All rights reserved.
机译：双酚A（BPA）在许多聚碳酸酯塑料，食品和饮料容器的环氧树脂衬里以及热敏纸的生产中被广泛使用。被污染饮食中的口服摄入被认为是人类双酚A暴露的主要来源。但是，由于热敏收据中的BPA含量很高，并且在我们的日常生活中应用广泛，因此，在保存热敏纸后，尤其是对于出纳员，应低估BPA转移到皮肤上的量。为了研究通过皮肤接触途径引起的BPA暴露水平的贡献以及BPA暴露水平与氧化性DNA损伤之间的关系，招募了六名男性志愿者，并要求他们在研究期间模拟出纳员的工作并处理热量收据。将三氯生（TCS，一种广泛用于个人健康和皮肤护理产品中的抗菌化合物）用作参考化合物。通过高效液相色谱/串联质谱仪（LC / MS / MS）测定其尿液中的BPA，TCS和8-羟基-2'-脱氧鸟苷（8-OHdG）浓度。结果表明，处理完热量接收后，志愿者的尿液中BPA浓度是实验期之前的3倍。但是尿液中TCS水平保持稳定。 BPA暴露与8-OHdG之间存在相关性（R-2 = 0.237，p <0.001），但TCS与8-OHdG浓度之间不存在相关性（R-2 = 0.026，p <0.777），表明更多的BPA暴露可能导致较高的氧化DNA损伤。尿液中8-OHdG水平的增加几乎与BPA一致，这表明处理热量接收会导致BPA摄入量增加，而BPA暴露与DNA氧化损伤相关。处理热量收据结束后的48小时后，尿液中的BPA含量未降至实验前的水平，这表明经皮肤接触的BPA排泄量超过48 h。通过皮肤接触途径的双酚A暴露对尿液中双酚A含量的贡献为51.9％至84％，出纳员的GM比率为70.9％，这表明以前的研究可能严重低估了出纳员的BPA。对于出纳员，应更多注意通过皮肤渗透引起的BPA暴露。 （C）2016 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environment international》 |2017年第1期|69-74|共6页
  • 作者

    Lv Yanshan; Lu Shaoyou; Dai Yanyan; Rui Caiyan; Wang Yongjun; Zhou Yuanxiu; Li Yanru; Pang Qihua; Fan Ruifang;

  • 作者单位

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China;

    South China Normal Univ, Sch Life Sci, Guangzhou Key Lab Subtrop Biodivers & Biomonitori, Guangzhou 510631, Guangdong, Peoples R China|Jinan Univ, Sch Environm, Guangzhou Key Lab Environm Exposure & Hlth, Guangzhou 510632, Guangdong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bisphenol A; Urine; 8-hydroxy-2 '-deoxyguanosine; Dermal absorption;

    机译：双酚A;尿;8-羟基-2'-脱氧鸟苷;皮肤吸收;

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