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首页> 外文期刊>Environment international >Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood
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Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood

机译:确定脐带血中产前微粒空气污染暴露和线粒体DNA含量的敏感窗口

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摘要

Introduction: Changes inmitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulatematter <= 2.5 mu m (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM2.5 exposure using mtDNA content measured in cord blood.
机译:简介:由于线粒体独特的基因组和相对缺乏修复系统,线粒体DNA(mtDNA)的变化可作为累积氧化应激(OS)的标志。在子宫内小于等于2.5微米(PM2.5)的颗粒物中,暴露会增强氧化应激。我们的目标是使用脐带血中测得的mtDNA含量,确定敏感窗口,以预测产前由于PM2.5暴露而导致的mtDNA损伤。

著录项

  • 来源
    《Environment international》 |2017年第1期|198-203|共6页
  • 作者单位

    Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA;

    Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA;

    Natl Inst Perinatol, Dept Neurobiol, Mexico City, DF, Mexico;

    Ben Gurion Univ Negev, Dept Geog & Environm Dev, POB 653, Beer Sheva, Israel;

    Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA;

    Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA;

    Minist Hlth, Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Cuernavaca, Morelos, Mexico;

    Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA;

    Icahn Sch Med Mt Sinai, Dept Pediat, Kravis Childrens Hosp, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA;

    Minist Hlth, Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Cuernavaca, Morelos, Mexico;

    Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA;

    Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA|Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Particulate matter; Mitochondrial DNA; Distributive lag models; Prenatal exposure;

    机译:颗粒物线粒体DNA分布滞后模型产前暴露;

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