...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Pollution >Persistent organic pollutants exposure in newborn dried blood spots and infant weight status: A case-control study of low-income Hispanic mother-infant pairs
【24h】

Persistent organic pollutants exposure in newborn dried blood spots and infant weight status: A case-control study of low-income Hispanic mother-infant pairs

机译：新生儿干血斑和婴幼儿的持久性有机污染物暴露：低收入西班牙母亲对的病例对照研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Persistent organic pollutants (POPs) are believed to alter metabolic homeostasis during fetal development, leading to childhood obesity. However, limited studies have explored how fetal chemical exposures relate to birth and infant weight outcomes in low-income Hispanic families at the highest risk of obesity. Therefore, we sought to determine associations between neonatal POPs exposure measured in newborn dried blood spots (DBS) and prenatal diet quality, birth weight, and overweight status at 18 months old. We conducted a case-control study nested within the Starting Early Program randomized controlled trial comparing POPs concentrations in infants with healthy weight (n = 46) and overweight status (n = 52) at age 18 months. Three categories of POPs, organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) were measured in archived newborn DBS. We assessed correlations between prenatal diet quality and neonatal POPs concentrations. Multivariable regression analyses examined associations between POPs (dichotomized at the mean) and birth weight z-score and weight status at 18 months, controlling for confounders. Seven of eight chemicals had detectable levels in greater than 94% of the sample. Higher protein, sodium and refined grain intake during pregnancy were correlated with lower POPs in newborn DBS. We found that high concentrations of perfluorooctanesulfonate (unstandardized coefficient [B]:-0.62, 95% confidence interval [CI]:-0.96 to-0.29) and perfluorohexanesulfate (B:-0.65, 95% CI:-0.99 to-0.31) were related to lower birth weight z-scores compared to those with low concentrations. We did not find associations between PBDEs, OCPs, and the other PFASs with birth weight z-scores, or between any POPs and weight status at 18 months. In conclusion, two PFASs were associated with lower birth weight, an important indicator of child health and growth, although direct associations with infant overweight status were not found. Whether neonatal POPs exposures contribute to economic and ethnic disparities in early obesity remains unclear. (c) 2020 Elsevier Ltd. All rights reserved.
机译：持久性有机污染物（POPs）被认为在胎儿发育过程中改变代谢稳态，导致儿童肥胖症。然而，有限的研究探索了胎儿化学曝光如何与低收入西班牙裔家庭的出生和婴儿重量结果有何肥胖的最高风险。因此，我们试图在新生儿干血斑（DBS）和产前饮食质量，出生体重和18个月的胎儿饮食质量，出生体重和超重状况下测量新生儿流行污染物暴露的关联。我们进行了一个案例对照研究，嵌套在开始早期的计划中随机控制试验，比较婴儿在18个月内具有健康体重（n = 46）和超重状况（n = 52）的婴儿的POPs浓度。在存档的新生DBS中测量了三类POP，有机氯杀虫剂（OCP），多溴二苯醚（PBDE）和全氟烷基物质（PFASS）。我们评估了产前饮食质量与新生儿Pops浓度之间的相关性。多变量回归分析，在18个月内检测Pops（平均值）和出生体重Z评分和体重状况之间的检查，控制混淆。八种化学品中有七种具有较大的样品的可检测水平。在妊娠期间较高的蛋白质，钠和精制的籽粒摄入与新生DBS中的低流行物相关。我们发现高浓度的全氟辛磺酸磺酸盐（非标准化系数[B]： - 0.62,95％置信区间[CI]： - 0.96至-0.29）和全氟己磺酸盐（B：-0.65,95％CI：-0.99至0.31）与低浓度的人相比，与较低出生体重Z分数有关。我们没有在18个月内发现PBDES，OCP和其他PFASS之间的关联，或在出生体重Z分数之间或任何POP和重量状态之间。总之，两种PFASS与较低的出生体重相关，虽然没有找到与婴儿超重状态的直接关联的儿童健康和增长的重要指标。新生儿流行曝光是否有助于早期肥胖的经济和族裔差异仍然不清楚。 （c）2020 elestvier有限公司保留所有权利。

著录项

  • 来源
    《Environmental Pollution》 |2020年第1期|115427.1-115427.9|共9页
  • 作者

    Gross Rachel S.; Ghassabian Akhgar; Vandyouse Sarvenaz; Messito Mary Jo; Gao Chongjing; Kannan Kurunthachalam; Trasande Leonardo;

  • 作者单位

    NYU Dept Pediat Grossman Sch Med New York NY 10016 USA|NYU Dept Populat Hlth Grossman Sch Med New York NY USA;

    NYU Dept Pediat Grossman Sch Med New York NY 10016 USA|NYU Dept Populat Hlth Grossman Sch Med New York NY USA|NYU Dept Environm Med Grossman Sch Med 550 1St Ave New York NY 10016 USA;

    NYU Dept Pediat Grossman Sch Med New York NY 10016 USA;

    NYU Dept Pediat Grossman Sch Med New York NY 10016 USA;

    New York State Dept Hlth Wadsworth Ctr Albany NY USA;

    NYU Dept Pediat Grossman Sch Med New York NY 10016 USA|New York State Dept Hlth Wadsworth Ctr Albany NY USA;

    NYU Dept Pediat Grossman Sch Med New York NY 10016 USA|NYU Dept Populat Hlth Grossman Sch Med New York NY USA|NYU Dept Environm Med Grossman Sch Med 550 1St Ave New York NY 10016 USA|NYU Wagner Sch Publ Serv New York NY USA|NYU Coll Global Publ Hlth New York NY USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Persistent organic pollutants; Pregnancy; Diet quality; Birth weight; Child obesity;

    机译：持续有机污染物;怀孕;饮食质量;出生体重;儿童肥胖;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号