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首页> 外文期刊>Environmental research >Ambient air pollution as a mediator in the pathway linking race/ethnicity to blood pressure elevation: The multi-ethnic study of atherosclerosis (MESA)
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Ambient air pollution as a mediator in the pathway linking race/ethnicity to blood pressure elevation: The multi-ethnic study of atherosclerosis (MESA)

机译：环境空气污染是种族/族裔与血压升高之间联系的中介体：动脉粥样硬化（MESA）的多族裔研究

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摘要

Background: Racial/ethnic disparities in blood pressure and hypertension have been evident in previous studies, as were associations between race/ethnicity with ambient air pollution and those between air pollution with hypertension. The role of air pollution exposure to racial/ethnic differences in hypertension has not been explored. Objective: To assess the potential mediating effects of ambient air pollution on the association between race/ ethnicity and blood pressure levels. Methods: We studied 6,463 White, Black, Hispanic and Chinese adults enrolled across 6 US cities. Systolic (SBP) and diastolic blood pressure (DBP) were measured at Exam 1 (2000-2002) and Exam 2 (2002-2004). Household-level annual average concentrations of fine particulate matter (PM_(2.5)), oxides of nitrogen (NO_x), and ozone (O_3) for the year 2000 were estimated for participants. Results: The difference in SBP levels by race/ethnicity that was related to higher PM_(2.5) concentrations compared with White men ("indirect associations") was 0.3 (95% CI: 0.1, 0.6) mmHg for Black men, 0.3 (95% CI: 0.1, 0.6) mmHg for Hispanic men and 1.0 (95% CI: 0.2, 1.8) mmHg for Chinese men. Findings were similar although not statistically significant for women. PM_(2.5) did not mediate racial/ethnic differences in DBP. Indirect associations were significant for O_3 for SBP among women and men and for DBP among men. In contrast, racial/ethnic disparities were attenuated due to exposure to NO_x. Conclusion: Racial disparities in blood pressure were reduced after accounting for PM_(2.5) and ozone while increased after accounting for NO_x.
机译：背景：在先前的研究中，血压和高血压的种族/族裔差异明显，种族/族裔与周围空气污染之间的关联以及与高血压之间的空气污染之间的关联也很明显。尚未探讨空气污染暴露对高血压种族/种族差异的作用。目的：评估环境空气污染对种族/种族与血压水平之间的关联的潜在中介作用。方法：我们研究了美国6个城市中的6,463名白人，黑人，西班牙裔和中国成年人。在考试1（2000-2002）和考试2（2002-2004）分别测量收缩压（SBP）和舒张压（DBP）。估计了2000年家庭中细颗粒物（PM_（2.5）），氮氧化物（NO_x）和臭氧（O_3）的年平均浓度。结果：与白人（“间接关联”）相比，与种族（种族）的SBP水平差异与PM_（2.5）浓度更高相关（黑人（“间接关联”））为0.3（95％CI：0.1、0.6）mmHg，黑人为0.3（95）西班牙裔男子的％CI：0.1，0.6）mmHg，中国男子为1.0（95％CI：0.2，1.8）mmHg。研究结果相似，尽管对女性而言没有统计学意义。 PM_（2.5）没有调解DBP中的种族/种族差异。间接关联对于男女SBP的O_3和男性DBP都是重要的。相反，由于暴露于NO_x，种族/族裔差异得到了缓解。结论：考虑了PM_（2.5）和臭氧后，血压的种族差异减小了，而考虑了NO_x后，血压的种族差异增大了。

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  • 来源
    《Environmental research》 |2020年第1期|18.1-18.9|共9页
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  • 作者单位

    Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD USA;

    Department of Environmental Health and Engineering Johns Hopkins University Bloomberg School of Public Health Baltimore MD USA;

    Department of Epidemiology University of Michigan School of Public Health Ann Arbor MI USA;

    Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD USA Department of Medicine Johns Hopkins School of Medicine Baltimore MD USA;

    Department of Environmental Health Sciences School of Public Health Columbia University Mailman School of Public Health New York NY USA;

    Department of Environmental and Occupational Health Sciences School of Public Health University of Washington Seattle WA USA;

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  • 正文语种 eng
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  • 关键词

    Air pollution; Blood pressure; Hypertension; Race/ethnicity; Disparities;

    机译：空气污染;血压;高血压;种族/民族;差距;

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