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首页> 外文期刊>Environmental research >Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort
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Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort

机译：利用加拿大东部队伍施工对有机和无机污染物的产前暴露的监测

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Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g(-1)), followed by acetaminophen detected in 53% of the samples (up to similar to 402 mu g g(-1)) and methyl paraben detected in 20% of the samples (up to similar to 10 mu g g(-1)). Pesticides were detected in low frequencies ( 2%) and low concentration ( 35 ng g(-1)). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants.
机译：评估子宫内有机物和多糖有机污染物的UTETO暴露是至关重要的，以更好地评估产前和产前发育的潜在有害影响。提出了新生儿的第一次肠道排放的粉末分析，作为评估累积产前暴露的非侵入性方式。本研究的目的是实施一种分析方法，其除了选定的元素（17个元素）外，还用于定量72个靶向有机化合物，包括在胎烷中的杀虫剂，药物化合物和日常生生物学。我们根据从加拿大东部（魁北克，加拿大）的396个Mechium样本的分析报告初始监测结果。在硝酸和过氧化物中消化后，通过质谱法分析胎聚体中的元素含量。通过固体 - 液体提取萃取靶向有机化合物并用MeConium萃取纯化，然后在串联质谱分析之前进行分散体纯化。靶向元素的浓度在欧洲和美国研究中报告的浓度范围内，但低于在发展中国家队列（即Pb，CD）中发现的浓度。在72个靶向有机化合物中，至少检测到31个，量化31，量化30。检测频率最高的化合物是咖啡因，在所有样品中检测到（从2.80至6186ng（-1）），然后在53％的样品中检测到乙酰氨基酚（最高可达402μg（-1））在20％的样品中检测到的甲基帕拉甲酯（最高可达10μg（-1））。在低频（<2％）和低浓度（<35ng（-1））中检测到杀虫剂。结果表明，粉末可用于监测胎儿的产前暴露于各种无机和有机污染物。

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