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首页> 外文期刊>Environmental research >Synergistic impact of co-exposures to toxic metals cadmium, lead, and mercury along with perfluoroalkyl substances on the healthy kidney function
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Synergistic impact of co-exposures to toxic metals cadmium, lead, and mercury along with perfluoroalkyl substances on the healthy kidney function

机译：共同曝光对有毒金属镉，铅和汞的协同影响以及健康肾功能上的全氟烷基物质

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摘要

Impact of co-exposures to toxic metals cadmium, lead, and mercury along with perfluoroalkyl substances on the healthy kidney function was evaluated among US adults aged = 20 years by analyzing data (N = 7857) from National Health and Nutrition Examination Survey for 2003-2014. Perfluoroalkyl substances selected for analysis were: perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA). High levels of exposures to Cd, Pb, total Hg, and PFAS were said to occur if their observed levels in blood/serum were greater than 75th percentiles. A healthy kidney function was defined if estimated glomerular filtration rate was found to be = 60 mL/min/1.73 m(2) and urine albumin creatinine ratio was = 30 mg/g creatinine. Adjusted odds of a healthy kidney function due to co-exposures to high levels of Cd along with high levels of PFOA, PFOS, and PFNA were found to be 0.713, 0.576, and 0.640 respectively. Adjusted odds of a healthy kidney function due to co-exposures to high levels of Pb along with high levels of PFOA, and PFNA were found to be 0.657, and 0.671 respectively. Co-exposures to high levels of Hg as measured by the total mercury in blood was not found to affect the odds of a healthy kidney function.
机译：通过分析来自2003年国家健康和营养考试调查的数据（N = 7857），在美国成年人中评估了合作肾功能镉，铅和汞与健康肾功能的全氟烷基物质以及2003年的营养考试调查-2014。选择分析的全氟烷基物质是：全氟辛酸（PFOA），全氟辛烷磺酸盐（PFOS），全氟己烷磺酸盐（PFHX）和全氟乙酸（PFNA）。据说，如果血液/血清的观察水平大于75百分位，则据说高水平的曝光率为Cd，Pb，总Hg和pfas。如果发现估计的肾小球过滤速率> = 60ml / min / 1.73m（2），并且尿白蛋白肌酐比率为<= 30mg / g肌酐，则定义了健康的肾功能。由于共同暴露于高水平的CD和高水平的PFOA，PFO和PFNA，调整了健康肾功能的几率分别为0.713,0.576和0.640。由于共同暴露于高水平的PF水平，调整了健康肾功能的几率以及高水平的PFOA和PFNA分别为0.657和0.671。未发现通过血液中总汞测量的高水平Hg的共同曝光，从而影​​响健康肾功能的几率。

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