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首页> 外文期刊>Environmental research >Lifelong exposure to multiple stressors through different environmental pathways for European populations
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Lifelong exposure to multiple stressors through different environmental pathways for European populations

机译：终身通过不同的环境途径暴露于多个压力源，用于欧洲人口

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摘要

Traditional exposure studies provide valuable insights for epidemiology, toxicology, and risk assessment. Throughout their lives, individuals are exposed to thousands of stressors in the environment which are not static, but influenced by environmental, temporal, spatial, and even socio-demographic factors. Existing exposure studies have usually focused on specific stressors for a constrained period of time. In response, the concept of the exposome has been raised, which is defined as the totality of exposure experienced from conception until death. The EU FP7-ENVIRONMENT research project HEALS was launched with the aim of incorporating a series of novel technologies, data analysis, and modelling tools to efficiently support exposome studies in Europe. The authors have developed a framework of modelling tools for estimating the long-term external exposure of selected population groups to multiple stressors through different pathways. As the starting point, the stressors, including electromagnetic fields (EMF) and ultraviolet light (UV) through dermal uptake, phthalates (DEHP, DIDP, and DINP) through inhalation, as well as chromium, mercury, and lead through food intake, have been selected. The simulation for multiple stressors has been realised by developing a probabilistic model that integrates the micro-environment approach, time-activity patterns, and a life course trajectory model. The methodology has been applied to a selected sample of subjects enrolled in the Italian Twin Registry (ITR). The results show that long-term exposures to multiple stressors are affected by factors including age, gender, geographical location, and education level. The methods developed in this paper extended the temporal and spatial scales of exposure modelling in Europe. Moreover, the application of our methods provided a novel approach and crucial input data for future work on environment-wide association studies.
机译：传统的曝光研究为流行病学，毒理学和风险评估提供了有价值的见解。在整个生命中，个人在环境中暴露在数千个不静态的压力源，而是受环境，时间，空间甚至社会人口因子的影响。现有的曝光研究通常集中在特定的压力源上，以获得受约束的时间。作为回应，提出了曝光的概念，该概念被定义为从概念中经历的暴露的整体，直到死亡。欧盟FP7-Environments研究项目愈合的目的是纳入一系列新颖的技术，数据分析和建模工具，以有效地支持欧洲的曝光研究。作者开发了一种建模工具的框架，用于通过不同的途径估算所选人群组的长期外部暴露于多个压力源。作为起始点，通过吸入的皮肤摄取，邻苯二甲酸酯（DeHP，DIDP和DinP）以及通过食物摄入量的皮肤摄取，邻苯二甲酸酯（DeHP，DIDP和DinP），包括电磁场（EMF）和紫外线（UV）。被选中了。通过开发概率模型实现了多个压力源的模拟，该模型集成了微环境方法，时间活动模式和寿命课程轨迹模型。该方法已应用于参加意大利语双书记符（ITR）的选定的受试者样本。结果表明，多个压力源的长期暴露受到包括年龄，性别，地理位置和教育水平的因素的影响。本文开发的方法延长了欧洲曝光建模的时间和空间尺度。此外，我们的方法应用提供了一种新的方法和关键的投入数据，以便将来的环境与环境 - 范围协会研究进行。

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  • 来源
    《Environmental research》 |2019年第12期|108744.1-108744.12|共12页
  • 作者

    Naixin Li; Rainer Friedrich; Cara N. Maesano; Emanuela Medda; Sonia Brescianini; Maria Antonietta Stazi; Clive E. Sabel; Dimosthenis Sarigiannis; Isabella Annesi-Maesano;

  • 作者单位

    Institute for Energy Economics and the Rational Use of Energy University of Stuttgart Heβbruehlstraβe 49a 70565 Stuttgart Germany;

    Institute for Energy Economics and the Rational Use of Energy University of Stuttgart Heβbruehlstraβe 49a 70565 Stuttgart Germany;

    Pierre Louis Institute of Epidemiology and Public Health Dept of Epidemiology of Allergic and Respiratory Disease Sorbonne University and INSERM Paris France;

    Istituto Superiore di Sanita Rome Italy;

    Istituto Superiore di Sanita Rome Italy;

    Istituto Superiore di Sanita Rome Italy;

    Department of Environmental Science Aarhus University Roskilde Denmark;

    Technologies Division - Environmental Engineering Laboratory Department of Chemical Engineering Aristotle University of Thessaloniki Thessaloniki Greece;

    Pierre Louis Institute of Epidemiology and Public Health Dept of Epidemiology of Allergic and Respiratory Disease Sorbonne University and INSERM Paris France;

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  • 正文语种 eng
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  • 关键词

    Exposome; EMF; UV; Phthalates; Food intake;

    机译：曝光;EMF;紫外线;邻苯二甲酸盐;食物的摄入量;

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