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首页> 外文期刊>Environmental research >Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review
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Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review

机译：人类中多溴联苯醚的曝光途径，水平和毒性：综述

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摘要

Polybrominated diphenyl ethers (PBDEs) are extensively used as brominated flame retardants (BFRs) in different types of materials, which have been listed as Persistent Organic Pollutants (POPs) by the Stockholm Convention in 2009 and 2017. Due to their ubiquities in the environment and toxicities, PBDEs have posed great threat to both human health and ecosystems. The aim of this review is to offer a comprehensive understanding of the exposure pathways, levels and trends and associated health risks of PBDEs in human body in a global scale. We systematically reviewed and described the scientific data of PBDE researches worldwide from 2010 to March 2020, focusing on the following three areas: (1) sources and human external exposure pathways of PBDEs; (2) PBDE levels and trends in humans; (3) human data of PBDEs toxicity. Dietary intake and dust ingestion are dominant human exposure pathways. PBDEs were widely detected in human samples, especially in human serum and human milk. Data showed that PBDEs are generally declining in human samples worldwide as a result of their phasing out. Due to the common use of PBDEs, their levels in humans from the USA were generally higher than that in other countries. High concentrations of PBDEs have been detected in humans from PBDE production regions and e-waste recycling sites. BDE-47, -153 and -99 were proved to be the primary congeners in humans. Human toxicity data demonstrated that PBDEs have extensively endocrine disruption effects, developmental effects, and carcinogenic effects among different populations.
机译：聚溴二苯醚（PBDES）广泛用作不同类型材料的溴化阻燃剂（BFR），2009年和2017年被斯德哥尔摩公约列为持久的有机污染物（POP）。由于它们在环境中的宽容不容毒性，PBDES对人类健康和生态系统构成了巨大威胁。本综述的目的是在全球范围内全面了解人体中PBDES的曝光途径，水平和趋势以及相关健康风险。我们从2010年到2020年到2010年3月到2020年系统地审查并描述了全球PBDE研究的科学数据，重点是以下三个方面：（1）群体的来源和人类外部暴露途径; （2）人类的PBDE水平和趋势; （3）毒性毒性的人体数据。膳食摄入和尘埃摄入是占主导地位的人体暴露途径。 PBDES在人类样品中广泛检测到，特别是在人体血清和人乳中。数据显示，由于它们的阶段，PBDES通常在全世界的人类样品中拒绝。由于PBDES的常见用途，来自美国人类的水平通常高于其他国家的水平。来自PBDE生产区的人类和电子废物回收位点的人类中检测到高浓度的PBDE。被证明BDE-47，-153和-99被证明是人类中的主要同源物。人类毒性数据表明，PBDE具有广泛的内分泌破坏效应，发育效果和不同群体中的致癌作用。

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  • 来源
    《Environmental research》 |2020年第8期|109531.1-109531.17|共17页
  • 作者

    Zhineng Wu; Chang He; Wei Han; Jie Song; Huijun Li; Yadi Zhang; Xiaohua Jing; Weidong Wu;

  • 作者单位

    School of Public Health Xinxiang Medical University Xinxiang 453003 China;

    Queensland Alliance for Environmental Health Science (QAEHS) The University of Queensland 4102 Brisbane Australia;

    College of Resources and Environment Northeast Agricultural University Harbin 150030 China;

    School of Public Health Xinxiang Medical University Xinxiang 453003 China;

    School of Public Health Xinxiang Medical University Xinxiang 453003 China;

    Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education) Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and Engineering Nankai University Tianjin 300350 China;

    School of Chemistry and Chemical Engineering Anyang Normal University Anyang 455002 China;

    School of Public Health Xinxiang Medical University Xinxiang 453003 China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    PBDEs; Exposure pathways; Biomonitoring; Trends; Toxicity;

    机译：PBDES;曝光途径;生物监测;趋势;毒性;

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