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首页> 外文期刊>Environmental research >Gestational and peripubertal phthalate exposure in relation to attention performance in childhood and adolescence
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Gestational and peripubertal phthalate exposure in relation to attention performance in childhood and adolescence

机译：妊娠和植物植物邻近植物期与青春期关注性能相关

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摘要

The prevalence of Attention Deficit/Hyperactivity Disorder (ADHD) has been increasing. Research suggests that exposure to endocrine disrupting chemicals such as phthalates may play a role, but studies of in utero phthalate exposure and ADHD-related symptoms beyond early childhood are limited. We investigated associations between measures of in utero phthalate exposure and ADHD symptoms, such as inattention and impulsivity, in childhood (age 6-11 years, n = 221) and in adolescence (age 9-18 years, n ＝ 200), as well as cross-sectional relationships between phthalate exposure and ADHD symptoms in adolescence (n = 491) among participants in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) cohort. Women provided urine samples up to three times during pregnancy and adolescents provided a urine sample at 9-18 years of age for phthalate metabolite measurement. We administered the Conners' Continuous Performance Test (CPT) when children were age 6-11 years and again at 9-18 years of age. We used multivariable linear regression to examine associations between the geometric mean of phthalate metabolite levels across pregnancy and CPT scores in childhood or adolescence separately, adjusting for age, years schooling (at 9-18 only), maternal education, and specific gravity. Although average in utero phthalate concentrations were not associated with CPT scores in childhood, interquartile range (IQR) increases of in utero MBzP, MCPP, and MBP were associated with 4.2%, 4.7%, and 4.5% (p＜0.05) higher Omissions scores in adolescence, respectively, indicating higher inattention. In utero MiBP levels were also associated with higher Inter-Stimulus Interval (ISI) and Variability scores (5.4% and 5.5% per IQR, p＜0.05) in adolescence. In addition, urinary DEHP metabolite levels during adolescence were cross-sectionally associated with poorer scores on several CPT indices indicating greater inattention. These findings suggest that in utero phthalate exposure may have adverse effects on attention, but these effects may not appear until adolescence, a period of extensive neurodevelopment. Future research investigating the long-term effects of in utero phthalate exposure on attention and ADHD in adolescence, as well as identification of potential mechanisms involved, is needed.
机译：注意力缺陷/多动障碍（ADHD）的发病率一直在增加。研究表明，暴露于内分泌干扰物，如邻苯二甲酸盐可能会起到一定的作用，但在子宫内接触邻苯二甲酸酯和ADHD相关症状超越幼儿教育研究的限制。我们研究协会在子宫内接触邻苯二甲酸酯的措施和多动症的症状，如注意力不集中和冲动之间，儿童（年龄6-11岁，N = 221），并在青春期（年龄9-18年中，n = 200），以及如邻苯二甲酸酯暴露和ADHD症状之间在青春期（= 491 n）的参与者在墨西哥环境毒物（ELEMENT）队列的早期生活曝光之间的横截面的关系。妇女在怀孕期间提供尿液样本最多三次和青少年在9-18岁的邻苯二甲酸酯代谢物的测量提供尿样。我们给予康纳斯连续性能测试（CPT），当孩子在9-18岁为年龄6-11岁又一遍。我们用多变量线性回归单独检查在儿童期或青春期跨越妊娠和CPT得分邻苯二甲酸酯代谢物水平的几何平均值之间的关联，在调整了年龄，受教育年限（只有9-18），母亲受教育程度和比重。虽然平均在子宫内的邻苯二甲酸浓度不与在童年CPT得分，四分位数间距（IQR）的子宫内MBzP，MCPP，和MBP增加与4.2％，4.7％，和4.5％相关（P <0.05）更高的遗漏的分数相关联在青春期，分别指示更高注意力不集中。在子宫内MIBP水平也具有较高的间刺激间隔（ISI）和在青春期变异分数（5.4％和每IQR 5.5％，P <0.05）相关联。此外，在青春期尿DEHP代谢物的水平横截面与较差的分数上显示更大的注意力不集中的几个CPT指数相关联。这些结果表明，在子宫内接触邻苯二甲酸酯可能对注意力的不利影响，但这些影响可能不会出现，直到青春期，一段丰富的神经发育的。未来的研究调查中对注意力和多动症子宫内接触邻苯二甲酸酯在青春期的长期影响，以及所涉及的潜在机制的识别，是必要的。

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  • 来源
    《Environmental research》 |2021年第5期|110911.1-110911.9|共9页
  • 作者

    Deborah J. Watkins; John D. Meeker; Marcela Tamayo-Ortiz; Brisa N. Sanchez; Lourdes Schnaas; Karen E. Peterson; Martha Maria Tellez-Rojo;

  • 作者单位

    Department of Environmental Health Sciences School of Public Health University of Michigan Ann Arbor MI USA;

    Department of Environmental Health Sciences School of Public Health University of Michigan Ann Arbor MI USA;

    National Council of Science and Technology National Institute of Public Health Mexico City Mexico;

    Department of Epidemiology and Biostatistics Drexel Dornsife School of Public Health Philadelphia PA USA;

    National Institute of Perinatology ABC Hospital Mexico City Mexico;

    Department of Environmental Health Sciences School of Public Health University of Michigan Ann Arbor MI USA Department of Nutritional Sciences School of Public Health University of Michigan Ann Arbor MI USA;

    Center for Nutrition and Health Research National Institute of Public Health Cuernavaca Mexico;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Phthalates; Attention; ADHD; Gestational exposure; Adolescence;

    机译：邻苯二甲酸盐;注意力;adhd;妊娠期曝光;青春期;

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