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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Associations of Gestational and Adolescent Phthalate Exposure with Performance Measures of ADHD Behaviors in Childhood and Adolescence
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Associations of Gestational and Adolescent Phthalate Exposure with Performance Measures of ADHD Behaviors in Childhood and Adolescence

机译：妊娠期和青少年邻苯二甲酸酯暴露与儿童和青少年多动症行为表现指标的关系

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Attention-Deficit/Hyperactivity Disorder (ADHD) prevalence has been increasing and studies suggest that exposure to endocrine disrupting chemicals such as phthalates may play a role. However, relationships between in utero phthalate exposure and long-term ADHD symptoms are uncertain. We investigated associations between phthalate levels across gestation and ADHD behaviors in childhood (n=217) and adolescence (n=200), as well cross-sectional associations in adolescence. Pregnant women provided urine samples during each trimester for phthalate measurement, and adolescents provided a urine sample at 9-18 years of age. We administered the Conners' Continuous Performance Test (CPT) when children were age 6-11 and 9-18 years. We used multiple linear regression to examine associations between gestational (geometric mean across pregnancy) or adolescent phthalate levels and CPT scores, adjusting for age, schooling (9-18 only), maternal education, and specific gravity. CPT scores for individual domains were weakly correlated between childhood and adolescence (Spearman r=0.08-0.38; n=195). In utero phthalate levels were not associated with childhood CPT scores. However, in utero MBzP, MCPP, and IDBP (MBP, MiBP) were associated with poorer Omissions scores in adolescence (4.2-4.7% increase in scores per interquartile range increase in exposure). In utero ZDBP was also associated with higher Response Style scores, indicating a preference for accuracy over speed. Concurrent ZDEHP exposure in adolescence was associated with poorer Hit Reaction Time (HRT) SD and Variability scores, while MCNP was associated with better HRT Block Change scores. Our findings suggest that in utero phthalate exposure may have long-term effects on ADHD behaviors that may not appear until adolescence, a period of substantial neurodevelopment. In addition, phthalate exposure during adolescence may also play a role in the development of ADHD behaviors.
机译：注意缺陷/多动障碍（ADHD）的患病率一直在增加，研究表明，暴露于内分泌干扰性化学物质（如邻苯二甲酸盐）可能起到一定作用。但是，宫内邻苯二甲酸酯暴露与长期ADHD症状之间的关系尚不确定。我们调查了整个妊娠期间邻苯二甲酸盐水平与儿童期（n = 217）和青春期（n = 200）的ADHD行为之间的关联，以及青春期的横断面关联。孕妇在每个孕期提供邻苯二甲酸盐测量的尿液样本，而青少年则在9-18岁时提供尿液样本。我们在6-11岁和9-18岁的儿童中进行了Conners持续表现测试（CPT）。我们使用多元线性回归分析了妊娠（妊娠期间的几何平均值）或青少年邻苯二甲酸盐水平与CPT评分之间的关​​联，并根据年龄，就学程度（仅9-18岁），孕产妇教育和比重进行了调整。儿童和青少年之间各个领域的CPT得分之间的相关性很弱（Spearman r = 0.08-0.38; n = 195）。子宫内邻苯二甲酸酯水平与儿童CPT评分无关。但是，在子宫内，MBzP，MCPP和IDBP（MBP，MiBP）与青春期的遗漏分数差（暴露水平每增加一个四分位数范围的分数增加4.2-4.7％）相关。在子宫内，ZDBP还与较高的回应风格得分相关联，表明对准确性的要求高于对速度的要求。青春期并发的ZDEHP暴露与较差的命中反应时间（HRT）SD和变异性评分相关，而MCNP与较好的HRT Block Change评分相关。我们的研究结果表明，子宫内邻苯二甲酸酯的暴露可能会对ADHD行为产生长期影响，直到青春期（一个重要的神经发育期）才可能出现。此外，青春期的邻苯二甲酸酯暴露也可能在多动症行为的发展中起作用。

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