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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Associations of Gestational and Adolescent Phthalate Exposure with Performance Measures of ADHD Behaviors in Childhood and Adolescence
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Associations of Gestational and Adolescent Phthalate Exposure with Performance Measures of ADHD Behaviors in Childhood and Adolescence

机译：妊娠期和青少年邻苯二甲酸盐的关联与儿童及青春期的ADHD行为绩效措施

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Attention-Deficit/Hyperactivity Disorder (ADHD) prevalence has been increasing and studies suggest that exposure to endocrine disrupting chemicals such as phthalates may play a role. However, relationships between in utero phthalate exposure and long-term ADHD symptoms are uncertain. We investigated associations between phthalate levels across gestation and ADHD behaviors in childhood (n=217) and adolescence (n=200), as well cross-sectional associations in adolescence. Pregnant women provided urine samples during each trimester for phthalate measurement, and adolescents provided a urine sample at 9-18 years of age. We administered the Conners' Continuous Performance Test (CPT) when children were age 6-11 and 9-18 years. We used multiple linear regression to examine associations between gestational (geometric mean across pregnancy) or adolescent phthalate levels and CPT scores, adjusting for age, schooling (9-18 only), maternal education, and specific gravity. CPT scores for individual domains were weakly correlated between childhood and adolescence (Spearman r=0.08-0.38; n=195). In utero phthalate levels were not associated with childhood CPT scores. However, in utero MBzP, MCPP, and IDBP (MBP, MiBP) were associated with poorer Omissions scores in adolescence (4.2-4.7% increase in scores per interquartile range increase in exposure). In utero ZDBP was also associated with higher Response Style scores, indicating a preference for accuracy over speed. Concurrent ZDEHP exposure in adolescence was associated with poorer Hit Reaction Time (HRT) SD and Variability scores, while MCNP was associated with better HRT Block Change scores. Our findings suggest that in utero phthalate exposure may have long-term effects on ADHD behaviors that may not appear until adolescence, a period of substantial neurodevelopment. In addition, phthalate exposure during adolescence may also play a role in the development of ADHD behaviors.
机译：注意力缺陷/多动障碍（ADHD）患病率越来越多，研究表明暴露于邻苯二甲酸盐等化学品的内分泌可能发挥作用。然而，在子宫邻苯二甲酸盐暴露和长期ADHD症状之间的关系是不确定的。我们在儿童时期（n = 217）和青春期（n = 200）中，在妊娠和ADHD行为中调查了邻苯二甲酸盐水平的关联，以及青春期的横截面关联。孕妇在每个三个月的肺酸盐测量期间提供尿样，并且青少年在9-18岁时提供了尿液样本。当孩子6-11岁和9-18岁时，我们管理Conners的连续性能测试（CPT）。我们使用了多元线性回归来检查妊娠（妊娠的几何平均值）或青少年邻苯二甲酸盐水平和CPT分数之间的关联，调整年龄，学校教育（仅限9-18），孕产妇教育和比重。为儿童和青春期（Spearman R = 0.08-0.38; n = 195）之间的CPT分数弱相关。在子宫内邻苯二甲酸盐水平与儿童CPT分数无关。然而，在UTEO MBZP，MCPP和IDBP（MBP，MBP）中与青春期的较差省略分数相关（4.2-4.7％的曝光范围增加4.2-4.7％）。在UTEO ZDBP中也与较高的响应风格分数相关，表明偏好于速度的精度。在青春期的同时Zdehp暴露与较差的反应时间（HRT）SD和变异分数相关，而MCNP与更好的HRT块变化分数相关。我们的研究结果表明，在子宫邻苯二甲酸盐暴露中可能对ADHD行为产生长期影响，直到青春期可能没有出现，这是一段大量神经发作的时期。此外，青春期期间的邻苯二甲酸盐暴露也可能在ADHD行为的发展中发挥作用。

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