首页> 外文期刊>Environmental research >The interactions among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of dopamine receptor D4 increase the risk of attention deficit/hyperactivity disorder in children
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The interactions among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of dopamine receptor D4 increase the risk of attention deficit/hyperactivity disorder in children

机译:有机磷酸酯农药暴露,氧化应激和多巴胺受体D4的遗传多态性之间的相互作用增加了儿童注意缺陷/多动障碍的风险

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摘要

Objective: The aim of this study was to clarify the association between organophosphate pesticides (OPs) and attention-deficit/hyperactivity disorder (ADHD) related to oxidative stress and genetic polymorphisms. Methods: This case-control study enrolled 93 children with ADHD and 112 control children in north Taiwan. Six dialkyl phosphate (DAP) metabolites of OPs and oxidative stress biomarkers were analyzed. Polymorphisms of the dopamine receptor D4 gene (DRD4) were identified. Results: Children with ADHD had significantly higher dimethylphosphate (DMP, 236.69 nmol/g cre. vs. 186.84 nmol/g cre., p value = 0.01) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA, 28.95 ug/g cre. vs. 16.55 μg/g cre., p value < 0.01) concentrations than control children. Children who carried DRD4 GA/AA genotypes (rs752306) were less likely than those who carried the DRD4 GG genotype to have ADHD (odds ratio [OR]: 0.45, 95% CI: 0.24-0.84). The estimated value of the AP (attributable proportion due to interaction) was 0.59 (95% CI: 0.13-1.05), indicating that 59% of ADHD cases in DMP-exposed children with the DRD4 GG genotype were due to the gene-environment interaction. After adjustment for other covariates, children who carried the DRD4 GG genotype, had been exposed to high DMP levels (more than the median), and had high HNE-MA levels had a significantly increased risk for developing ADHD (OR = 11.74, 95% CI: 2.12-65.04). Conclusion: This study indicated a gene-environment interaction in the risk of ADHD in children. The association between DMP and ADHD in children might relate to the mechanism of lipid peroxidation. Dose-response relationships and the combined effects of OPs, oxidative stress, and genetic polymorphism on ADHD should not be neglected.
机译:目的:本研究旨在阐明有机磷酸酯农药(OPs)与与氧化应激和遗传多态性有关的注意力缺陷/多动症(ADHD)之间的关系。方法:该病例对照研究招募了台湾北部的93名多动症儿童和112名对照儿童。分析了OPs和氧化应激生物标志物的六种磷酸二烷基酯(DAP)代谢产物。确定了多巴胺受体D4基因(DRD4)的多态性。结果:患有多动症的儿童的磷酸二甲酯(DMP,236.69 nmol / g cre。相对于186.84 nmol / g cre。,p值= 0.01)和4-羟基-2-壬烯-巯基癸酸(HNE-MA,28.95 ug)明显更高。 / g cres与16.55μg/ g cre。,p值<0.01)的浓度高于对照组儿童。携带DRD4 GA / AA基因型(rs752306)的儿童比携带DRD4 GG基因型的儿童患ADHD的可能性更低(赔率[OR]:0.45,95%CI:0.24-0.84)。 AP的估计值(可归因于相互作用的比例)为0.59(95%CI:0.13-1.05),表明在DMP暴露的DRD4 GG基因型儿童中,ADHD病例的59%是由于基因与环境的相互作用。在对其他协变量进行调整后,携带DRD4 GG基因型,暴露于高DMP水平(高于中位数)并且HNE-MA高水平的儿童患ADHD的风险显着增加(OR = 11.74,95% CI:2.12-65.04)。结论:这项研究表明基因-环境相互作用对儿童多动症的危险性。小儿DMP和ADHD之间的关系可能与脂质过氧化的机制有关。剂量-反应关系以及OPs,氧化应激和遗传多态性对ADHD的综合影响不容忽视。

著录项

  • 来源
    《Environmental research》 |2018年第1期|339-346|共8页
  • 作者单位

    Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, 155, Sec. 2, Linong Street, Taipei 11, Taiwan;

    Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, 155, Sec. 2, Linong Street, Taipei 11, Taiwan;

    Department of Pediatrics, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan;

    Department of Child and Adolescent Psychiatry, Taipei City Hospital, Songde Branch, Taipei, Taiwan;

    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taiwan;

    Department of Pediatrics, Taipei City Hospital, Yangming Branch, Taipei, Taiwan;

    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei, Taiwan;

    Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan;

    Department of Child and Adolescent Psychiatry, Taipei City Hospital, Songde Branch, Taipei, Taiwan;

    Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan;

    Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming University, 155, Sec. 2, Linong Street, Taipei 11, Taiwan;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Organophosphate pesticides; Attention deficit/hyperactivity disorder; Oxidative stress; Dopamine receptor D4 gene; Additive interaction;

    机译:有机磷农药;注意缺陷/多动症;氧化应激多巴胺受体D4基因;加性相互作用;

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