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Blood lead levels and hypothalamic-pituitary-adrenal function in middle-aged individuals

机译：中年人的血铅水平和下丘脑-垂体-肾上腺功能

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摘要

Experimental and epidemiological studies suggested that exposure to lead (Pb) may influence the hypothalamic-pituitary-adrenal (HPA) axis. However, previous studies have yielded mixed results. We evaluated changes in basal salivary Cortisol levels and acute Cortisol responsivity to psychological stress in relation with blood Pb levels (BPb), in Caucasian individuals 50-67 years of age. Data were collected through the Study of Genetics, Stress and Cognitive Development (2004-2006). Diurnal basal and stress-reactive salivary Cortisol levels were collected and BPb levels were determined using inductively coupled plasma mass spectroscopy. A total of 65 participants were included in the current study. General linear mixed models were used to assess the association between BPb level and change in Cortisol secretion over time, for diurnal basal pattern and stress-reactive partem, respectively. The geometric mean BPb was 2.70 μg/dL ( ± 1.44) and two exposure groups were created based on the median value of 2.48 μg/dL No difference in geometric mean of salivary Cortisol (μg/dL) at awakening was observed between High and Low BPb groups (0.23 ( ± 0.11) vs 0.20 ( ± 0.11), p = 0.36). The overall pattern of change in both diurnal basal (from the awakening to bedtime) and reactive salivary Cortisol (during the stress induction protocol) did not differ between groups. In these middle-aged and older adults, we concluded that Pb exposure, within the range observed in the current study, was associated with neither diurnal nor stress-reactive Cortisol secretion. Further investigation with larger datasets are needed to confirm our observations.
机译：实验和流行病学研究表明，铅（Pb）暴露可能会影响下丘脑-垂体-肾上腺（HPA）轴。但是，先前的研究得出了不同的结果。我们评估了50-67岁高加索人的基础唾液皮质醇水平和急性皮质醇对心理压力的反应与血铅水平（BPb）的关系。数据通过遗传学，压力和认知发展研究（2004-2006年）收集。收集昼夜基础和压力反应性唾液皮质醇水平，并使用电感耦合等离子体质谱法测定BPb水平。本研究共有65名参与者。通用线性混合模型分别用于评估昼夜基础模式和应激反应型同龄人的BPb水平与皮质醇分泌随时间变化之间的关联。几何平均血压BPb为2.70μg/ dL（±1.44），并且根据中值2.48μg/ dL创建了两个暴露组。醒觉时唾液皮质醇的几何平均数（μg/ dL）没有差异。 BPb组（0.23（±0.11）vs 0.20（±0.11），p = 0.36）。两组之间昼夜基础（从觉醒到就寝时间）和唾液反应性皮质醇（在压力诱导方案期间）的总体变化模式没有差异。在这些中老年人中，我们得出的结论是，在当前研究中观察到的范围内，铅的暴露与昼夜或应激反应性皮质醇的分泌均无关。需要使用更大的数据集进行进一步调查，以确认我们的观察结果。

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  • 来源
    《Environmental research》 |2018年第1期|554-561|共8页
  • 作者

    Gerard Ngueta; Marc-Andre Verner; Alexandra J. Fiocco; Sonia Lupien; Pierrich Plusquellec;

  • 作者单位

    Department of Occupational and Environmental Health, Universite' de Montreal Montreal, Canada,Universite de Montreal Public Health Research Institute, Montreal Canada;

    Department of Occupational and Environmental Health, Universite' de Montreal Montreal, Canada,Universite de Montreal Public Health Research Institute, Montreal Canada;

    Department of Psychology, Ryerson University, Toronto, Canada;

    Center for Studies on Human Stress, Montreal Mental Health University Institute, Montreal Canada,Department of Psychiatry, Universite de Montreal, Montreal Canada;

    Center for Studies on Human Stress, Montreal Mental Health University Institute, Montreal Canada,School of Psychoeducation, Universite de Montreal Montreal Canada;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Lead exposure; Cortisol secretion; Stress responsivity; Adults;

    机译：铅接触;皮质醇分泌;压力响应能力;大人;

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