Abstract Alteration of host-pathogen interactions in the wake of climate change - Increasing risk for shellfish associated infections?
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Alteration of host-pathogen interactions in the wake of climate change - Increasing risk for shellfish associated infections?

机译:气候变化后宿主-病原体相互作用的改变-贝类相关感染的风险增加了吗?

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AbstractThe potential for climate-related spread of infectious diseases through marine systems has been highlighted in several reports. With this review we want to draw attention to less recognized mechanisms behind vector-borne transmission pathways to humans. We have focused on how the immune systems of edible marine shellfish, the blue mussels and Norway lobsters, are affected by climate related environmental stressors. Future ocean acidification (OA) and warming due to climate change constitute a gradually increasing persistent stress with negative trade-off for many organisms. In addition, the stress of recurrent hypoxia, inducing high levels of bioavailable manganese (Mn) is likely to increase in line with climate change. We summarized that OA, hypoxia and elevated levels of Mn did have an overall negative effect on immunity, in some cases also with synergistic effects. On the other hand, moderate increase in temperature seems to have a stimulating effect on antimicrobial activity and may in a future warming scenario counteract the negative effects. However, rising sea surface temperature and climate events causing high land run-off promote the abundance of naturally occurring pathogenicVibrioand will in addition, bring enteric pathogens which are circulating in society into coastal waters. Moreover, the observed impairments of the immune defense enhance the persistence and occurrence of pathogens in shellfish. This may increase the risk for direct transmission of pathogens to consumers. It is thus essential that in the wake of climate change, sanitary control of coastal waters and seafood must recognize and adapt to the expected alteration of host-pathogen interactions.HighlightsStressors induced by climate changes are causing immunosuppressed invertebrates with impaired bacteriostatic capacity.Climate changes increase distribution and abundance of human pathogens in coastal waters.Resulting in: Increased risk for pathogen transmission to shellfish consumers Need for more reliable pathogen indicators.
机译: 摘要 与气候有关的传染病通过海洋系统传播的潜力在几份报告中得到了强调。通过这篇综述,我们希望引起人们对媒介传播给人类的传播途径背后未被广泛认识的机制的关注。我们已经集中研究了食用海洋贝类,蓝贻贝和挪威龙虾的免疫系统如何受到气候相关环境压力的影响。未来海洋酸化(OA)和气候变化导致的变暖构成了持续增加的持续压力,并且对许多生物造成了负面的折衷。此外,反复缺氧的压力会导致高水平的生物利用锰(Mn)随气候变化而增加。我们总结说,OA,缺氧和锰水平升高确实对免疫产生了总体负面影响,在某些情况下还具有协同作用。另一方面,温度的适度升高似乎对抗菌活性具有刺激作用,并且可能在未来的变暖情况下抵消这种不利影响。然而,海平面温度升高和导致高地表径流量的气候事件促进了自然产生的致病性弧菌的丰富,此外,还将使社会中循环传播的肠道病原体进入沿海水域。此外,观察到的免疫防御功能受损会增强贝类中病原体的持久性和发生率。这可能会增加病原体直接传播给消费者的风险。因此,至关重要的是,在气候变化之后,沿海水域和海产品的卫生控制必须认识并适应宿主-病原体相互作用的预期变化。 < / ce:abstract> 突出显示 •• 由气候变化引起的压力导致免疫抑制的无脊椎动物的抑菌能力下降。 < ce:list-item id =“ u0075”> 气候变化增加了沿海水域中人类病原体的分布和数量。 导致:病原体传播给贝类消费者的风险增加需要更可靠的病原体指标。

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