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Arsenic in drinking water and adverse birth outcomes in Ohio

机译：俄亥俄州的饮用水中砷和不良分娩结果

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摘要

Background: Arsenic in drinking water has been associated with adverse reproductive outcomes in areas with high levels of naturally occurring arsenic. Less is known about the reproductive effects of arsenic at lower levels. Objectives: This research examined the association between low-level arsenic in drinking water and small for gestational age (SGA), term low birth weight (term LBW), very low birth weight (VLBW), preterm birth (PTB), and very preterm birth (VPTB) in the state of Ohio. Methods: Exposure was defined as the mean annual arsenic concentration in drinking water in each county in Ohio from 2006 to 2008 using Safe Drinking Water Information System data. Birth outcomes were ascertained from the birth certificate records of 428,804 births in Ohio from the same time period. Multivariable generalized estimating equation logistic regression models were used to assess the relationship between arsenic and each birth outcome separately. Sensitivity analyses were performed to examine the roles of private well use and prenatal care utilization in these associations. Results: Arsenic in drinking water was associated with increased odds of VLBW (AOR 1.14 per ug/L increase; 95% CI 1.04, 1.24) and PTB (AOR 1.10; 95% CI 1.06, 1.15) among singleton births in counties where < 10% of the population used private wells. No significant association was observed between arsenic and SGA, or VPTB, but a suggestive association was observed between arsenic and term LBW. Conclusions: Arsenic in drinking water was positively associated with VLBW and PTB in a population where nearly all (> 99%) of the population was exposed under the current maximum contaminant level of 10 ug/L. Current regulatory standards may not be protective against reproductive effects of prenatal exposure to arsenic.
机译：背景：在自然砷含量高的地区，饮用水中的砷与不良的生殖结果有关。对于较低水平的砷的生殖作用知之甚少。目的：这项研究检查了饮用水中低水平砷与小胎龄（SGA），足月低出生体重（足月LBW），极低出生体重（VLBW），早产（PTB）和极早足之间的关系在俄亥俄州的出生（VPTB）。方法：使用安全饮用水信息系统数据，将暴露定义为2006年至2008年俄亥俄州各县饮用水中的年平均砷浓度。从同一时期俄亥俄州的428,804例出生证明记录中确定了出生结局。使用多变量广义估计方程逻辑回归模型分别评估砷与每个出生结局之间的关系。进行了敏感性分析，以检查私人协会使用和产前保健利用在这些协会中的作用。结果：在<10的县，单胎出生的婴儿中饮用水中的砷与VLBW（Aug 1.14 / ug / L增加； 95％CI 1.04，1.24）和PTB（AOR 1.10; 95％CI 1.06，1.15）的几率增加相关人口的百分比使用了私人井。在砷和SGA或VPTB之间未观察到显着关联，但在砷和足月LBW之间观察到暗示性关联。结论：在当前最大污染物水平10 ug / L下，几乎所有人群（> 99％）都暴露于饮用水中，砷与VLBW和PTB呈正相关。当前的法规标准可能无法防止产前砷暴露对生殖的影响。

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  • 来源
    《Environmental research》 |2017年第8期|52-59|共8页
  • 作者

    Kirsten S. Almberg; Mary E. Turyk; Rachael M. Jones; Kristin Rankin; Sally Freels; Judith M. Graber; Leslie T. Stayner;

  • 作者单位

    Epidemiology and Biostatistics Division, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60607, USA;

    Epidemiology and Biostatistics Division, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60607, USA;

    Environmental and Occupational Health Sciences Division, University of Illinois at Chicago, School of Public Health, 2121 W. Taylor Street, Chicago, IL 60612, USA;

    Epidemiology and Biostatistics Division, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60607, USA;

    Epidemiology and Biostatistics Division, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60607, USA;

    Epidemiology and Biostatistics Division, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60607, USA,Epidemiology Department, Rutgers the State University of New Jersey, School of Public Health, 683 Hoes Lane West, Piscataway, NJ 08854, United States;

    Epidemiology and Biostatistics Division, University of Illinois at Chicago, School of Public Health, 1603 W. Taylor Street, Chicago, IL 60607, USA;

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  • 正文语种 eng
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  • 关键词

    Arsenic; Preterm birth; Birth weight; Small for gestational age; Drinking water;

    机译：砷;早产;出生体重;胎龄小;饮用水;

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