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Effect of season of birth on cord blood IgE and IgE at birth: A systematic review and meta-analysis

机译:出生季节对脐带血IgE和出生时IgE的影响:系统评价和荟萃分析

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摘要

Background: Elevated cord blood IgE is important on the pathway to allergic disease. The association between season of birth and infant cord blood IgE is not well-established. Study findings differ on which birth season is associated with higher cord blood IgE risk and its magnitude. We conducted a systematic review and metaanalysis of studies on season of birth and cord blood IgE. Methods: We searched Medline, Web of Science, Scopus and ProQuest Health databases, and reviewed reference lists of articles that met the inclusion criteria. All included studies measured IgE as a binary variable using various cut-off values. We performed multivariate-random-effects meta-analysis to handle an exposure with multiple categories of Season of Birth. Results: Our search identified 275 records and 10 had sufficient data to be included in a meta-analysis. Relative to summer, winter birth had the greatest odds of high IgE (≥ 0.1 IU/ml), meta-analysis OR = 1.24 (95%CI: 1.01-1.52). A similar OR, was found for IgE > 0.5 IU/ml, OR = 1.30 (95%CI: 0.99-1.71). Conclusions: A winter season of birth was associated with statistically significant higher odds of elevated cord blood IgE at cut-off > 0.1 IU/ml but borderline at cut-off > 0.5 IU/ml. This winter effect is likely to be a marker for a range of other environmental exposures during specific stages of pregnancy, such as aeroallergen exposures, maternal infections and vitamin D levels. Further research is required to support our finding and to identify the exact mechanisms that lead to the winter season of birth effect on circulating IgE levels, as this may have implications for allergic disease prevention.
机译:背景:脐血IgE升高在过敏性疾病的发病途径中很重要。出生季节与婴儿脐带血IgE之间的关联尚不明确。关于哪个出生季节与更高的脐血IgE风险及其严重程度相关的研究发现存在差异。我们对出生季节和脐带血IgE进行了系统的综述和荟萃分析。方法:我们搜索了Medline,Web of Science,Scopus和ProQuest Health数据库,并查看了符合纳入标准的文章参考列表。所有纳入的研究均使用各种截断值将IgE测量为二进制变量。我们进行了多元随机效应荟萃分析,以处理出生季节多个类别的暴露。结果:我们的搜索确定了275条记录,其中10条具有足够的数据以纳入荟萃分析。相对于夏季,冬季出生的人发生高IgE(≥0.1 IU / ml)的几率最高,荟萃分析OR = 1.24(95%CI:1.01-1.52)。对于IgE> 0.5 IU / ml,OR = 1.30(95%CI:0.99-1.71),发现了相似的OR。结论:出生的冬季与临界值> 0.1 IU / ml时脐血IgE升高的统计学显着较高机率相关,而临界值> 0.5 IU / ml时临界血IgE升高的可能性更高。在怀孕的特定阶段,这种冬季效应很可能是一系列其他环境暴露的标志,例如空气过敏原暴露,孕产妇感染和维生素D水平。需要进一步的研究来支持我们的发现,并确定导致冬季出生对循环IgE水平产生影响的确切机制,因为这可能对预防过敏性疾病有影响。

著录项

  • 来源
    《Environmental research》 |2017年第8期|198-205|共8页
  • 作者单位

    School of Public Health, La Trobe University, Bundoora, Vic, Australia,Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia;

    Cancer Council of Victoria, Melbourne, Vic 3004, Australia;

    Department of Mathematics and Statistics, La Trobe University, Bundoora, Vic, Australia;

    Allergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Australia;

    Allergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Australia;

    Allergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Australia;

    Allergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Australia;

    Woolcock Institute of Medical Research, The University of Sydney, Glebe, New South Wales, Australia,South Western Sydney Clinical School, University of New South Wales, Liverpool, New South Wales, Australia,Ingham Institute of Applied Medical Research, University of New South Wales, Liverpool New South Wales, Australia;

    Department of Allergy and Clinical Immunology and Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne 3052, Australia;

    Centre for International Health, University of Bergen, Norway and Department Occupational Medicine, Haukelan, University Hospital, Bergen, Norway;

    Institute of Epidemiology I, Helmholtz Zentrum Miinchen - German Research Center for Environmental Health, Ingolstadter Landstraβse 1, 85764 Neuherberg, Germany,Institute and Outpatient Clinic for Occupational Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich (LMU), Munich, Germany;

    School of Public Health and Preventive Medicine,Monash University,Melbourre;

    School of Public Health, La Trobe University, Bundoora, Vic, Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cord blood; IgE; Meta-analysis; Pollen; Season of birth;

    机译:脐带血;IgE;荟萃分析;花粉;出生季节;

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