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首页> 外文期刊>Environmental research >Development and application of a novel method to characterize methylmercury exposure in newborns using dried blood spots
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Development and application of a novel method to characterize methylmercury exposure in newborns using dried blood spots

机译：利用干血斑表征新生儿甲基汞暴露的新方法的开发和应用

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摘要

Background: Methylmercury (MeHg) is a pollutant of global concern. While there is a need to gauge early-life exposures, there remain outstanding ethical, financial, and practical challenges with using the preferred biomarker, whole blood, notably in pregnant women, infants, toddlers, and children. Dried bloodspots (DBS) may help overcome some of these challenges. Notably DBS are collected from newborns in many jurisdictions offering an institutionalized platform to efficiently characterize exposures. Objective: To develop, validate, and apply a new method to measure MeHg levels in DBS with a specific aim to use this method to increase understanding of newborn exposures. Methods: Method development and validation was pursued by consulting U.S. EPA Method 1630 and other resources. The method was applied to measure MeHg levels in DBS from newborns (n = 675) from the Michigan BioTrust for Health program. Results: The assay's detection limit (0.3 µg/L), accuracy (96-115% of expected), precision, linearity, and range met performance criteria guidelines. In the newborn DBS samples, the mean (SD) and geometric mean values of MeHg were 1.46 (0.90) and 1.25 µg/L respectively, and ranged from 0.09 to 9.97 µg/L. The values we report here are similar to cord blood mercury values reported elsewhere. Conclusions: This is the first characterization of MeHg exposure in newborns, and thus fills an important data gap as prior studies have focused on pregnant women, cord blood, or toddlers. This method helps overcome technical challenges associated with other proposed approaches, and moving ahead there is great promise for applying this DBS-based method for population-level surveillance, particularly in resource-limited settings and for children's health.
机译：背景：甲基汞（MeHg）是全球关注的污染物。尽管需要评估早期生命暴露，但在使用首选生物标志物，全血时，尤其在孕妇，婴儿，学步儿童和儿童中，仍然存在着巨大的伦理，财务和实践挑战。干血斑（DBS）可能有助于克服其中一些挑战。值得注意的是，DBS是从许多辖区的新生儿那里收集的，提供了一个制度化的平台来有效地描述暴露情况。目的：开发，验证和应用一种新的方法来测量DBS中的MeHg水平，具体目的是使用此方法来增进对新生儿暴露的了解。方法：方法开发和验证是通过咨询美国EPA方法1630和其他资源进行的。该方法用于测量密歇根州生物信托健康计划的新生儿（n = 675）DBS中的MeHg水平。结果：测定的检出限（0.3 µg / L），准确度（预期的96-115％），精密度，线性和范围均符合性能标准指南。在新生儿DBS样品中，MeHg的平均值（SD）和几何平均值分别为1.46（0.90）和1.25 µg / L，范围为0.09至9.97 µg / L。我们在这里报告的值类似于在其他地方报告的脐带血汞值。结论：这是新生儿甲基汞暴露的第一个特征，因此填补了重要的数据空白，因为先前的研究集中在孕妇，脐带血或学步儿童上。这种方法有助于克服与​​其他拟议方法相关的技术挑战，因此，将这种基于DBS的方法应用于人口级监视（尤其是在资源有限的环境和儿童健康中）具有很大的希望。

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  • 来源
    《Environmental research》 |2017年第11期|276-282|共7页
  • 作者

    Niladri Basu; Jenny W.L. Eng; Marie Perkins; Andrea Santa-Rios; Gordana Martincevic; Krystin Carlson; Richard L. Neitzel;

  • 作者单位

    Faculty of Agricultural and Environmental Sciences, McGill University, Montreal Quebec, Canada,Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA;

    Faculty of Agricultural and Environmental Sciences, McGill University, Montreal Quebec, Canada;

    Faculty of Agricultural and Environmental Sciences, McGill University, Montreal Quebec, Canada;

    Faculty of Agricultural and Environmental Sciences, McGill University, Montreal Quebec, Canada;

    Faculty of Agricultural and Environmental Sciences, McGill University, Montreal Quebec, Canada;

    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA;

    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA;

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  • 正文语种 eng
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  • 关键词

    Mercury; Biomonitoring; Bloodspots; Exposure science; Methods development; Surveillance; Pregnancy; Public health;

    机译：汞;生物监测;血斑;接触科学;方法开发;监视怀孕;公共卫生;

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