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首页> 外文期刊>Environmental research >Thyroid antagonists and thyroid indicators in U.S. pregnant women in the Vanguard Study of the National Children's Study
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Thyroid antagonists and thyroid indicators in U.S. pregnant women in the Vanguard Study of the National Children's Study

机译：美国国家儿童研究的先锋研究中美国孕妇的甲状腺拮抗剂和甲状腺指标

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摘要

The sodium iodide-symporter (NIS) mediates uptake of iodide into thyroid follicular cells. This key step in thyroid hormone synthesis is inhibited by perchlorate, thiocyanate (SCN) and nitrate (NO_3) anions. When these exposures occur during pregnancy the resulting decreases in thyroid hormones may adversely affect neurodevelopment of the human fetus. Our objectives were to describe and examine the relationship of these anions to the serum thyroid indicators, thyroid stimulating hormone (TSH) and free thyroxine (FT4), in third trimester women from the initial Vanguard Study of the National Children's Study (NCS); and to compare urine perchlorate results with those in pregnant women from the National Health and Nutritional Examination Survey (NHANES). Urinary perchlorate, SCN, NO_3, and iodine, serum TSH, FT4, and cotinine were measured and a food frequency questionnaire (FFQ) was administered to pregnant women enrolled in the initial Vanguard Study. We used multiple regression models of FT4 and TSH that included perchlorate equivalent concentration (PEC, which estimates combined inhibitory effects of the anions perchlorate, SCN, and NO_3 on the NIS). We used multiple regression to model predictors of each urinary anion, using FFQ results, drinking water source, season of year, smoking status, and demographic characteristics. Descriptive statistics were calculated for pregnant women in NHANES 2001-2012. The geometric mean (CM) for urinary perchlorate was 4.04 μg/L, for TSH 1.46 mlU/L, and the arithmetic mean for FT4 1.11 ng/dL in 359 NCS women. In 330 women with completed FFQs, consumption of leafy greens, winter season, and Hispanic ethnicity were significant predictors of higher urinary perchlorate, which differed significantly by study site and primary drinking water source, and bottled water was associated with higher urinary perchlorate compared to filtered tap water. Leafy greens consumption was associated with higher urinary NO_3 and higher urinary SCN. There was no association between urinary perchlorate or PEC and TSH or FT4, even for women with urinary iodine ＜ 100 μg/L GM urinary perchlorate concentrations in the full sample (n=494) of third trimester NCS women (4.03 μg/L) were similar to pregnant women in NHANES (3.58 μg/L).
机译：碘化钠符号（NIS）介导碘化物吸收到甲状腺滤泡细胞中。高氯酸根，硫氰酸根（SCN）和硝酸根（NO_3）阴离子抑制甲状腺激素合成的这一关键步骤。当这些暴露在怀孕期间发生时，甲状腺激素的减少可能会对人类胎儿的神经发育产生不利影响。我们的目的是描述和检查这些阴离子与国家儿童研究的先锋研究（NCS）最初的三个月妇女的血清甲状腺指标，甲状腺刺激激素（TSH）和游离甲状腺素（FT4）的关系；并将尿液中的高氯酸盐结果与美国国家健康与营养检查（NHANES）孕妇的结果进行比较。测量了尿中的高氯酸盐，SCN，NO_3和碘，血清TSH，FT4和可替宁，并向参加“先锋研究”的孕妇进行了食物频率问卷调查（FFQ）。我们使用了FT4和TSH的多个回归模型，其中包括高氯酸盐当量浓度（PEC，该模型估计了高氯酸根阴离子，SCN和NO_3对NIS的综合抑制作用）。我们使用FFQ结果，饮用水水源，一年中的季节，吸烟状况和人口统计学特征，使用多元回归对每种尿阴离子的预测因子进行建模。在NHANES 2001-2012中计算了孕妇的描述性统计数据。在359名NCS妇女中，高氯酸尿的几何平均值（CM）为4.04μg/ L，TSH为1.46 mlU / L，FT4的算术平均值为1.11 ng / dL。在330名完成FFQ的女性中，食用绿叶蔬菜，冬季和西班牙裔是高尿酸高氯的重要指标，这在研究地点和主要饮用水水源上有显着差异，与过滤后的水相比，瓶装水与高尿酸高的尿素相关。自来水。绿叶蔬菜的消费与较高的尿NO_3和较高的尿SCN有关。尿碘＜100μg/ L的妇女，在整个妊娠中期NCS妇女（4.03μg/ L）的全部样本（n = 494）中，高碘尿酸盐浓度＜100μg/ L的女性，均无相关性。与孕妇的NHANES（3.58μg/ L）相似。

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  • 来源
    《Environmental research》 |2016年第8期|179-188|共10页
  • 作者

    Mary E. Mortensen; Rebecca Birch; Lee-Yang Wong; Liza Valentin-Blasini; Elizabeth B. Boyle; Kathleen L. Caldwell; Lori S. Merrill; John Moye Jr.; Benjamin C. Blount;

  • 作者单位

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States,Division of Laboratory Sciences, MS F-20, 4770 Buford Highway, Atlanta, GA 30341, United States;

    Westat, Inc., Rockville, MD, United States;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States;

    Westat, Inc., Rockville, MD, United States;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States;

    Westat, Inc., Rockville, MD, United States;

    NCS Program Office, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes for Health, Bethesda, MD, United States;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    National Children's Study; Perchlorate; Biomonitoring; NHANES; Pregnancy;

    机译：国家儿童研究;高氯酸盐生物监测;HAN怀孕;

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