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首页> 外文期刊>Environmental Science & Technology >Contaminant Exposure Linked to Cellular and Endocrine Biomarkers in Southern California Bottlenose Dolphins
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Contaminant Exposure Linked to Cellular and Endocrine Biomarkers in Southern California Bottlenose Dolphins

机译：污染物暴露与南加州宽吻海豚中的细胞和内分泌生物标志物相关

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摘要

Cetaceans in the Southern California Bight (SCB) are exposed to high levels of halogenated organic contaminants (HOCs), which have previously been linked to impaired reproductive health and immune responses. We used a combination of molecular tools to examine the potential physiological impacts of HOC exposure in two bottlenose dolphin (Tursiops truncatus) ecotypes in the SCB. We quantified 25 HOCs in the blubber of 22 biopsies collected from males between 2012 and 2016. We then analyzed genome-wide gene expression in skin using RNA-sequencing and measured blubber testosterone to compare HOC exposure with cellular and endocrine biomarkers. We found high levels of HOCs in both ecotypes with significantly higher total polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), tris(4-chlorophenyl)methanol (TCPMOH), and chlordane-related compounds in the coastal ecotype versus the offshore ecotype. We found evidence of PBDE bioaccumulation in both ecotypes, however, the pattern of bioaccumulation or endocrine disruption for other HOCs was different between the ecotypes, suggesting potential endocrine disruption in the coastal ecotype. We also observed correlations between HOCs and gene coexpression networks enriched for xenobiotic metabolism, hormone metabolism, and immune response that could indicate cellular effects from HOC exposure. By integrating measurements of HOC load with both transcriptome profiling and endocrine biomarkers, our approach provides insight into HOC exposure and potential impacts on wild cetacean health in southern California.
机译：南加州湾（SCB）中的鲸类动物暴露于高水平的卤代有机污染物（HOC），这些污染物以前与生殖健康和免疫反应受损有关。我们使用分子工具的组合来检查SCB中两种宽吻海豚（Tursiops truncatus）生态型中HOC暴露的潜在生理影响。我们对2012年至2016年间从男性身上采集的22份活检样本中的25个HOC进行了定量。然后，我们使用RNA测序技术分析了皮肤中全基因组基因的表达，并测量了脂肪睾丸激素，以将HOC暴露与细胞和内分泌生物标志物进行比较。我们发现与沿海生态型相比，两种生态型中的HOC含量较高，总多氯联苯（PCB），多溴联苯醚（PBDEs），三（4-氯苯基）甲醇（TCPMOH）和与氯丹相关的化合物的总含量显着更高。我们发现在两种生态型中都有PBDE生物富集的证据，但是，其他HOC的生物富集或内分泌破坏模式在这些生态型之间是不同的，表明沿海生态型中潜在的内分泌破坏。我们还观察到HOC与丰富的异源代谢，激素代谢和免疫应答的基因共表达网络之间的相关性，这可能表明HOC暴露会对细胞产生影响。通过将HOC负载的测量结果与转录组图谱分析和内分泌生物标志物进行整合，我们的方法可以洞悉HOC暴露以及对南加州野生鲸类健康的潜在影响。

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  • 来源
    《Environmental Science & Technology》 |2019年第7期|3811-3822|共12页
  • 作者

    Trego Marisa L.; Hoh Eunha; Whitehead Andrew; Kellar Nicholas M.; Lauf Morgane; Datuin Dana O.; Lewison Rebecca L.;

  • 作者单位

    San Diego State Univ, Dept Biol, 5500 Campanile Dr, San Diego, CA 92182 USA|Univ Calif Davis, Dept Environm Toxicol, 1 Shields Ave, Davis, CA 95616 USA;

    San Diego State Univ, Sch Publ Hlth, 5500 Campanile Dr, San Diego, CA 92182 USA;

    Univ Calif Davis, Dept Environm Toxicol, 1 Shields Ave, Davis, CA 95616 USA;

    NOAA, Ocean Associates, Contract Southwest Fisheries Sci Ctr, Natl Marine Fisheries Serv, Arlington, VA 22207 USA;

    NOAA, Ocean Associates, Contract Southwest Fisheries Sci Ctr, Natl Marine Fisheries Serv, Arlington, VA 22207 USA;

    San Diego State Univ, Sch Publ Hlth, 5500 Campanile Dr, San Diego, CA 92182 USA;

    San Diego State Univ, Dept Biol, 5500 Campanile Dr, San Diego, CA 92182 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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