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首页> 外文期刊>Environmental Science & Technology >Relative Effect Potency Estimates for Dioxin-Like Compounds in Pregnant Women with Gestational Diabetes Mellitus and Blood Glucose Outcomes Based on a Nested Case-control Study
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Relative Effect Potency Estimates for Dioxin-Like Compounds in Pregnant Women with Gestational Diabetes Mellitus and Blood Glucose Outcomes Based on a Nested Case-control Study

机译：基于嵌套案例对照研究的妊娠糖尿病患者的二恶英样化合物的相对效应效应估计

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摘要

To improve the applicability of the toxic equivalents principle for human health risk assessment, systemic relative effect potencies (REPs) for dioxin-like compounds (DLCs) deriving from human in vivo data are required. A prospective nested case-control study was performed to determine REPs from the human serum concentration of DLCs using gestational diabetes mellitus (GDM) and fasting blood glucose (FBG) as the end points of concern. Serum concentration of 29 DLCs from 77 cases and 154 controls were measured. Logistic and linear regression were used to estimate the effects of individual congeners on GDM and FBG, respectively. The REPs based on GDM and FBG were calculated from the ratios of regression coefficients, beta(i(DLCs))/beta(TCDD). Two sets of consistent human serum-based REPs, that is, GDM-REP and FBG-REP, were established and largely agree with REPs from other human studies. These human-serum REPs show much smaller variation compared to the 4 to 5 orders of magnitude span in REPs database for the present WHO-TEF determination. Moreover, the established REPs fitted well with WHO-TEFs, especially for polychlorinated dibenzo-p-dioxins, furans. These REPs reflecting real human exposure scenarios exhibited validity and could be used to improve health risk assessment of human body burden of DLCs.
机译：为了提高有毒等同物的适用性，需要用于衍生自体内数据的二恶英样化合物（DLC）的全身相对效应效应（Reps）。进行前瞻性嵌套病例对照研究，以使用妊娠期糖尿病（GDM）和空腹血糖（FBG）确定来自DLC的人血清浓度的代表作为终点的关注点。测量来自77例和154例对照的29dLC的血清浓度。物流和线性回归分别用于分别估计单个同源物对GDM和FBG的影响。基于GDM和FBG的REP，从回归系数，β（I（DLC））/β（TCDD）的比率计算。建立了两套一致的人血清血清代表，即GDM-rep和FBG-rep，并在很大程度上同意来自其他人类研究的代表。与目前的WHO-TEF确定相比，这些人类血清代表与REPS数据库中的4至5个数量级跨度相比显示得更小。此外，已建立的代表与WHO-TEF合理，特别是对于多氯二苯脲-P-二恶英，呋喃。这些代表反映了真正的人体暴露情景表现出有效性，可用于改善人体对DLC的健康风险评估。

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  • 来源
    《Environmental Science & Technology》 |2019年第13期|7792-7802|共11页
  • 作者

    Liu Xin; Zhang Lei; Li Jingguang; Wang Jun; Meng Guimin; Chi Min; Zhao Yunfeng; Wu Yongning;

  • 作者单位

    China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Beijing 100021 Peoples R China|Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

    China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Beijing 100021 Peoples R China;

    China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Beijing 100021 Peoples R China|Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

    Shenzhen Ctr Chron Dis Control Shenzhen 518020 Peoples R China;

    Beijing Fengtai Hosp Obstet & Gynecol Beijing 100071 Peoples R China;

    China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Beijing 100021 Peoples R China|Taiyuan Ctr Dis Control & Prevent Taiyuan 030000 Shanxi Peoples R China;

    China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Beijing 100021 Peoples R China;

    China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Beijing 100021 Peoples R China|Nanchang Univ State Key Lab Food Sci & Technol Nanchang 330047 Jiangxi Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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