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首页> 外文期刊>Environmental Science & Technology >Metabolic Responses of Mytilus galloprovincialis to Fullerenes in Mesocosm Exposure Experiments
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Metabolic Responses of Mytilus galloprovincialis to Fullerenes in Mesocosm Exposure Experiments

机译：介壳层暴露实验中鸡没食子虫对富勒烯的代谢反应

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摘要

In this study, Mediterranean mussels ( Mytilus galloprovincialis ) were exposed through the diet to fullerene soot at three concentrations in parallel to a control group. Their metabolomics response was assessed by high-performance liquid chromatography coupled to high-resolution mass spectrometry (HPLC–HRMS). The experiments were conducted in marine mesocosms, during 35 days (7 days of acclimatization, 21 days of exposure, and 7 days of depuration). Real conditions were emulated in terms of physicochemical conditions of the habitat. Results confirmed the bioaccumulation of fullerenes, and the metabolome of the exposed organisms revealed significant differences in the concentrations of seven free amino acids in comparison to the control group. An increase in small nonpolar amino acids (e.g., alanine) and branched chain amino acids (leucine and isoleucine) were observed. Also, glutamine concentrations decreased significantly, suggesting the activation of facultative anaerobic energy metabolism. Branched chain amino acids, such as leucine and isoleucine, followed the opposite trend after the highest level of exposure, which can imply hormesis effects. Other significant differences were observed on lipids content, such as the general increase of free fatty acids, i.e., long-chain fatty acids (lauric, myristic, and palmitic acids) when the concentration of exposure was increased. These results were consistent with hypoxia and oxidative stress.
机译：在这项研究中，地中海贻贝（Mytilus galloprovincialis）通过饮食被暴露于与对照组平行的三种浓度的富勒烯烟灰中。他们的代谢组学反应通过高效液相色谱与高分辨率质谱法（HPLC-HRMS）进行了评估。实验是在35天（适应7天，接触21天和净化7天）的海洋中膜环境中进行的。根据栖息地的物理化学条件模拟了实际条件。结果证实了富勒烯的生物蓄积性，与对照组相比，暴露生物的代谢组显示出七个游离氨基酸的浓度存在显着差异。观察到小的非极性氨基酸（例如丙氨酸）和支链氨基酸（亮氨酸和异亮氨酸）增加。另外，谷氨酰胺浓度显着降低，表明兼性厌氧能量代谢被激活。最高暴露水平后，亮氨酸和异亮氨酸等支链氨基酸呈相反的趋势，这可能暗示着兴奋作用。在脂质含量上还观察到其他显着差异，例如当暴露浓度增加时，游离脂肪酸，即长链脂肪酸（月桂酸，肉豆蔻酸和棕榈酸）普遍增加。这些结果与缺氧和氧化应激一致。

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  • 来源
    《Environmental Science & Technology》 |2018年第3期|1002-1013|共12页
  • 作者

    Josep Sanchís; Marta Llorca; Mar Olmos; Gabriella F. Schirinzi; Cristina Bosch-Orea; Esteban Abad; Damià Barceló; Marinella Farré;

  • 作者单位

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain,Catalan Institute of Water Research (ICRA), C/Emili Grahit 101, 17003 Girona, Catalonia, Spain;

    Institute of Environmental Assessment and Water Research (IDAEA-CSIC), C/Jordi Girona, 18-26, 08034 Barcelona, Catalonia, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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