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首页> 外文期刊>Environmental Science & Technology >Effects of 4-Hydroxyphenyl 4-lsoprooxyphenylsulfone (BPSIP) Exposure on Reproduction and Endocrine System of Zebrafish
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Effects of 4-Hydroxyphenyl 4-lsoprooxyphenylsulfone (BPSIP) Exposure on Reproduction and Endocrine System of Zebrafish

机译：4-羟苯基4-异丙氧基苯基砜（BPSIP）暴露对斑马鱼繁殖和内分泌系统的影响

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摘要

The compound 4-hydroxyphenyl 4-isoprooxyphenylsulfone (BPSIP), a derivative of bisphenol S (BPS), has been detected in thermal paper and human urine samples; however, its potential effects on the endocrine system are largely unknown. The present study was conducted to determine the adverse effects of BPSIP on egg production, relative organ weights, plasma levels of sex hormones, and transcription of genes related to the hypothalamus-pituitary-gonad (HPG) axis in zebrafish ( Danio rerio ). In male fish, the gonadosomatic index was significantly decreased at concentrations of 5 and 50 μg/L BPSIP. The estrogenic (increase in the 17β-estradiol/testosterone [E2/T] ratio) and antiandrogenic (decrease in T) effects were observed in fish exposed to BPSIP and males were more sensitive to the adverse effects than females. The changes in sex hormones were supported by the regulation of genes along the HPG axis, such as cyp19 , 17βhsd , and cyp17 transcripts. Although the effective concentration for endocrine disruption was greater than that of BPS, the actions of BPSIP on the steroidogenic pathway were similar to the effects of BPS exposure.
机译：在热敏纸和人类尿液样品中检测到了双酚S（BPS）的衍生物4-羟苯基4-异丙氧基苯砜（BPSIP）。然而，其对内分泌系统的潜在影响尚不清楚。本研究旨在确定BPSIP对斑马鱼（Danio rerio）的产蛋量，相对器官重量，血浆性激素水平以及与下丘脑-垂体性腺（HPG）轴相关基因的转录的不利影响。在雄鱼中，当浓度为5和50μg/ L BPSIP时，性腺体指数显着降低。在暴露于BPSIP的鱼中观察到雌激素作用（17β-雌二醇/睾丸激素比[E2 / T]的增加）和抗雄激素作用（T的降低），并且雄性比雌性对不良反应更为敏感。性激素的变化受到沿HPG轴的cyp19，17βhsd和cyp17转录本等基因调控的支持。尽管内分泌干扰的有效浓度大于BPS，但BPSIP对类固醇生成途径的作用类似于BPS暴露的作用。

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  • 来源
    《Environmental Science & Technology》 |2018年第3期|1506-1513|共8页
  • 作者

    Jiyun Lee; Na-Youn Park; Younglim Kho; Kyunghee Ji;

  • 作者单位

    Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea;

    Department of Health, Environment and Safety, Eulji University, Seongnam, Gyeonggi, 13135, Republic of Korea;

    Department of Health, Environment and Safety, Eulji University, Seongnam, Gyeonggi, 13135, Republic of Korea;

    Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea,Department of Occupational and Environmental Health, Yongin University, Yongin, 17092, Republic of Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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