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Factors Shaping the Human Exposome in the Built Environment: Opportunities for Engineering Control

机译：塑造人类暴露环境的因素：工程控制的机会

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摘要

The "exposome" is a term describing the summation of one's lifetime exposure to microbes and chemicals. Such exposures are now recognized as major drivers of human health and disease. Because humans spend ∼90% of their time indoors, the built environment exposome merits particular attention. Herein we utilize an engineering perspective to advance understanding of the factors that shape the built environment exposome and its influence on human wellness and disease, while simultaneously informing development of a framework for intentionally controlling the exposome to protect public health. Historically, engineers have been focused on controlling chemical and physical contaminants and on eradicating microbes; however, there is a growing awareness of the role of "beneficial" microbes. Here we consider the potential to selectively control the materials and chemistry of the built environment to positively influence the microbial and chemical components of the indoor exposome. Finally, we discuss research gaps that must be addressed to enable intentional engineering design, including the need to define a "healthy" built environment exposome and how to control it.
机译：“暴露体”是描述一个人一生中暴露于微生物和化学物质的总和的术语。现在，这种接触被认为是人类健康和疾病的主要驱动力。由于人类将90％的时间都花在室内，因此建筑环境的暴露尤其值得关注。在此，我们利用工程学的观点来加深对影响建筑环境暴露的因素及其对人类健康和疾病的影响的了解，同时通知开发有意控制暴露的框架以保护公众健康的框架。从历史上看，工程师一直专注于控制化学和物理污染物以及消灭微生物。但是，人们越来越意识到“有益”微生物的作用。在这里，我们认为有可能选择性地控制建筑环境的材料和化学性质，从而对室内暴露体的微生物和化学成分产生积极影响。最后，我们讨论了实现有目的的工程设计必须解决的研究空白，包括定义“健康”构建环境的必要性以及如何控制它。

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  • 来源
    《Environmental Science & Technology》 |2017年第14期|7759-7774|共16页
  • 作者

    Dai Dongjuan; Prussin Aaron J.; Marr Linsey C.; Vikesland Peter John; Edwards Marc A.; Pruden Amy;

  • 作者单位

    Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute, State University, Blacksburg, VA, United States;

    Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute, State University, Blacksburg, VA, United States;

    Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute, State University, Blacksburg, VA, United States;

    Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute, State University, Blacksburg, VA, United States;

    Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute, State University, Blacksburg, VA, United States;

    Via Department of Civil and Environmental Engineering, Virginia Polytechnic Institute, State University, Blacksburg, VA, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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