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首页> 外文期刊>Environmental Science & Technology >Urinary Excretion of Phthalate Metabolites in School Children of China: Implication for Cumulative Risk Assessment of Phthalate Exposure
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Urinary Excretion of Phthalate Metabolites in School Children of China: Implication for Cumulative Risk Assessment of Phthalate Exposure

机译：中国小学生邻苯二甲酸酯尿的排泄：邻苯二甲酸酯暴露的累积风险评估的意义。

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摘要

We analyzed 13 metabolites of 9 phthalates in urine of 782 Chinese school children aged 8-11 years and estimated the daily intake for phthalates based on urinary metabolite levels. The daily intakes were compared with acceptable intake levels to calculate the hazard quotient (HQ) for single phthalate. Finally, the cumulative risk for each child was assessed by means of a hazard index (HI) which is the sum of HQs. Overall, 11 metabolites were found in at least 85% of the urine samples with the highest median concentration of 47.1 ng/mL (93-4 μg/g creatinine) for mono-n- butyl phthalate (MnBP). Monooctyl phthalate (MOP) and monoisononyl phthalate (MiNP) were not detectable. The cumulative risk assessment covering di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DnBP), di-isobutyl phthalate (DiBP), and butyl-benzyl phthalate (BBzP) demonstrated that 19.8% (volume model-based) and 40.3% (creatinine model-based) of the children exceeded 1 for the HI based on tolerable daily intake (TDI) values (considered as potential adverse antiandrogenic effect). Furthermore, at least 36% of the children from the manufacturing-intensive region had a HI higher than 1. The results indicate that Chinese children are widely exposed to phthalates and those from manufacturing-intensive regions are probably at a high risk of cumulative phthalate exposure.
机译：我们分析了782名8-11岁中国小学生尿液中9种邻苯二甲酸盐的13种代谢物，并根据尿中代谢物的含量估算了邻苯二甲酸盐的每日摄入量。将每日摄入量与可接受的摄入量进行比较，以计算单种邻苯二甲酸酯的危险系数（HQ）。最后，通过危险指数（HI）评估每个孩子的累积风险，该指数是总部的总和。总体而言，在至少85％的尿液样本中发现11种代谢物，邻苯二甲酸单正丁酯（MnBP）的最高中值浓度为47.1 ng / mL（93-4μg/ g肌酐）。无法检测到邻苯二甲酸单辛酯（MOP）和邻苯二甲酸单异壬酯（MiNP）。涵盖邻苯二甲酸二（2-乙基己基）酯（DEHP），邻苯二甲酸二正丁酯（DnBP），邻苯二甲酸二异丁酯（DiBP）和邻苯二甲酸丁苄酯（BBzP）的累积风险评估表明，该风险率为19.8％（体积模型为根据可耐受的每日摄入量（TDI）值（被认为是潜在的抗雄激素作用），有40.3％（基于肌酐模型的）儿童的HI超过1。此外，来自制造业密集地区的儿童中，至少有36％的HI高于1。结果表明，中国儿童广泛接触邻苯二甲酸盐，而来自制造业密集地区的儿童可能面临累积邻苯二甲酸盐暴露的高风险。 。

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  • 来源
    《Environmental Science & Technology》 |2015年第2期|1120-1129|共10页
  • 作者

    Bin Wang; Hexing Wang; Wei Zhou; Yue Chen; Ying Zhou; Qingwu Jiang;

  • 作者单位

    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032 China;

    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032 China;

    Department of Geriatrics, The Affiliated Taizhou Hospital of Wenzhou Medical University, Linhai City, Zhejiang, 317000, China;

    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada KIN 6N5;

    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032 China;

    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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