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首页> 外文期刊>Environmental Science & Technology >Toxicity Evaluation of Exposure to an Atmospheric Mixture of Polychlorinated Biphenyls by Nose-Only and Whole-Body Inhalation Regimens
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Toxicity Evaluation of Exposure to an Atmospheric Mixture of Polychlorinated Biphenyls by Nose-Only and Whole-Body Inhalation Regimens

机译：仅通过鼻子和全身吸入方案评估暴露于多氯联苯的大气混合物中的毒性

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摘要

The health risk of inhalation exposure to polychlorinated biphenyls (PCB) cannot be assessed with high confidence due to the lack of rigorous inhalation studies. One uncertainty rests on exposure regimen, as whole-body exposure systems allow oral PCB intake that confounds the exposure. We conducted contemporaneous PCB inhalation exposures with whole-body and nose-only exposure methods. Female Sprague-Dawley rats were concurrently exposed to vapor-phase PCBs (533 ± 93 μg/m~3) generated from PCB 11-supplemented Chicago Air Mixture resembling the Chicago airshed, 4 h/day, 6 days/week, for 4 weeks. Congener-specific analysis showed 1.5-fold higher ΣPCBs in the lungs of nose-only exposed than the whole-body exposed animals (p = 0.0024). Higher ΣPCB concentrations were also found in the sera, livers, brains, and adipose tissue of nose-only exposed animals (1.1-1.5-fold), but these increases were not statistically significant. Congener profiles of five tissue types were dominated by PCB 28/31 and higher-chlorinated congeners in both groups reflecting rapid metabolism of other lower-chlorinated PCBs. No toxicity was seen regarding metabolic enzyme expression, glutathione, or histopathology. However, diminished weight gain and reduced plasma total thyroxine levels were found in both groups compared with controls, after exposure to 76 μg/m~3 ΣPCBs as adjusted for continuous exposure. Hepatic lipid peroxidation was also elevated in the nose-only group. Our study shows that prolonged nose-only exposure was well-tolerated and eliminated the need for housing animals outside the vivarium, thus was preferred for long-term PCB inhalation studies.
机译：由于缺乏严格的吸入研究，因此不能高信度评估吸入多氯联苯（PCB）的健康风险。一种不确定性取决于暴露方案，因为全身暴露系统允许口服PCB摄入而混淆了暴露。我们使用全身和仅鼻子接触方法进行了PCB吸入接触的同时接触。将雌性Sprague-Dawley大鼠同时暴露于由PCB 11补充的类似于芝加哥空气流域的芝加哥空气混合物产生的气相PCB（533±93μg/ m〜3），持续4周/天，6天/周，持续4周。同系物特异性分析显示，仅鼻子暴露的肺部的ΣPCB比全身暴露的动物高1.5倍（p = 0.0024）。在仅鼻子暴露的动物的血清，肝，脑和脂肪组织中也发现更高的ΣPCB浓度（1.1-1.5倍），但这些增加在统计学上并不显着。两种组织中五种组织类型的同源物谱均以PCB 28/31和高氯化物同源物为主，这反映了其他低氯化物PCB的快速代谢。关于代谢酶的表达，谷胱甘肽或组织病理学没有发现毒性。然而，与对照组相比，两组患者在连续调整暴露于76μg/ m〜3ΣPCBs后，均发现体重减轻和血浆总甲状腺素水平降低。仅鼻子组的肝脂质过氧化也升高。我们的研究表明，延长的仅鼻子暴露是可以耐受的，并且消除了在动物舍外饲养动物的需要，因此，对于长期的PCB吸入研究，它是首选。

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  • 来源
    《Environmental Science & Technology》 |2015年第19期|11875-11883|共9页
  • 作者

    Xin Hu; Andrea Adamcakova-Dodd; Hans-Joachim Lehmler; Katherine Gibson-Corley; Peter S. Thorne;

  • 作者单位

    Department of Occupational and Environmental Health, Iowa City, Iowa 52242, United States;

    Department of Occupational and Environmental Health, Iowa City, Iowa 52242, United States;

    Department of Occupational and Environmental Health, Iowa City, Iowa 52242, United States;

    Department of Pathology, University of Iowa, Iowa City, Iowa 52242, United States;

    Department of Occupational and Environmental Health, Iowa City, Iowa 52242, United States,Department of Occupational and Environmental Health, The University of Iowa, College of Public Health, 145 N. Riverside, S341A CPHB, Iowa City, IA 52242, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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