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New Insights into Traditional Health Risk Assessments of Mercury Exposure: Implications of Selenium

机译：传统的汞暴露健康风险评估的新见解：硒的含义

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摘要

There is increasing evidence that selenium (Se) has a significant effect on mercury (Hg) toxicology; however, Hg exposure risk assessments usually consider only the amount of Hg present in the environment or in food. On the basis of the present understanding of mechanisms of interaction between Se and Hg, the physiology/toxicology of Se, and the toxicology of Hg, we propose a new criterion for Se/Hg exposure assessment This criterion, which is based on Se-Hg interactions, considers not only the toxicological consequences of Hg exposure but also the benefits and/or adverse effects of Se intake, especially the adverse effects related to a Se deficiency/excess. According to an illustrative assessment based on the new criterion and nine existing criteria, large knowledge gaps in the traditional assessments of exposure to Hg and/or Se were found, including those that assessed the interactions between Hg and Se. These results suggest that future assessments of Hg exposure (or Se intake) should include both Se and Hg.
机译：越来越多的证据表明硒对汞的毒理学有重要影响。但是，汞暴露风险评估通常仅考虑环境或食物中存在的汞量。在目前对硒与汞相互作用的机理，硒的生理/毒理学和汞的毒理学的认识的基础上，我们提出了硒/汞暴露评估的新标准。该标准基于硒-汞相互作用不仅考虑了汞暴露的毒理学后果，而且考虑了硒摄入的益处和/或不利影响，尤其是与硒缺乏/过量有关的不利影响。根据基于新标准和九个现有标准的说明性评估，发现传统的汞和/或硒暴露评估中存在巨大的知识空白，包括那些评估汞和硒之间相互作用的知识空白。这些结果表明，未来对汞暴露（或硒摄入量）的评估应同时包括硒和汞。

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  • 来源
    《Environmental Science & Technology》 |2014年第2期|1206-1212|共7页
  • 作者

    Hua Zhang; Xinbin Feng; Hing Man Chan; Thorjorn Larssen;

  • 作者单位

    Norwegian Institute for Water Research (NIVA), Gaustadalleen 21, 0349 Oslo, Norway,State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, 550002, China;

    State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, 550002, China;

    Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario Canada K1N 6NS;

    Norwegian Institute for Water Research (NIVA), Gaustadalleen 21, 0349 Oslo, Norway;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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