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首页> 外文期刊>Environmental Science & Technology >Biomarkers of Manganese Exposure in Pregnant Women and Children Living in an Agricultural Community in California
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Biomarkers of Manganese Exposure in Pregnant Women and Children Living in an Agricultural Community in California

机译：加利福尼亚农业社区孕妇和儿童锰暴露的生物标志物

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摘要

Manganese (Mn) is an essential nutrient but at high exposure levels is a neurotoxicant There is no well-validated biomarker to assess perinatal Mn exposure. A total of 75 mother-child pairs provided blood, urine, and/or deciduous tooth samples. We analyzed Mn in dentin and enamel of shed teeth; maternal, cord, and child blood; and maternal and child urine and examined the interrelationships of Mn levels in all matrices. We observed higher Mn levels in prenatal than postnatal dentin (geometric mean (GM) = 0.51 vs 0.16 Mn:Ca, p ＜ 0.001), maternal blood at delivery than 26 weeks gestation (GM = 20.7 vs. 14.6 μg/L, p = 0.001), and cord blood than child blood at 24 months of age (39.9 vs 25.0 μg/L, p = 0.005). There were no significant correlations between Mn in dentin and Mn concentrations in maternal blood or maternal or child urine. Levels of Mn in prenatal dentin, prenatal maternal blood, and 24 month urine were higher (p ＜ 0.05) among mothers and children living with a farm worker. Prenatal Mn levels in dentin were correlated with Mn loadings and concentrations in prenatal house dust. Levels of Mn measured in tooth dentin constitute a promising biomarker of perinatal exposure.
机译：锰（Mn）是必不可少的营养素，但在高暴露水平下是一种神经毒性物质。目前尚无有效的生物标志物来评估围产期Mn暴露。总共75对母子提供了血液，尿液和/或乳牙样本。我们分析了牙本质和脱落牙釉质中的锰。母血，脐带血和儿童血；以及母婴尿液，并检查了所有基质中Mn水平的相互关系。我们观察到，产前血中的锰水平高于产后牙本质（几何平均（GM）= 0.51 vs 0.16 Mn：Ca，p ＜0.001），分娩时的孕妇血液高于妊娠26周（GM = 20.7 vs. 14.6μg/ L，p = 0.001），并且脐带血比24个月大时的儿童血（39.9 vs 25.0μg/ L，p = 0.005）。牙本质中的Mn与母体血液或母体或儿童尿液中的Mn浓度之间无显着相关性。在农场工人的母亲和儿童中，产前牙本质，产前孕妇血液和24个月尿中的锰含量较高（p ＜0.05）。牙本质中的产前锰水平与产前屋尘中的锰含量和浓度相关。牙本质中测得的锰含量构成围产期暴露的有前途的生物标志物。

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  • 来源
    《Environmental Science & Technology》 |2014年第24期|14695-14702|共8页
  • 作者

    Robert B. Gunier; Ana Maria Mora; Donald Smith; Manish Arora; Christine Austin; Brenda Eskenazi; Asa Bradman;

  • 作者单位

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California 94704, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California 94704, United States,Central American Institute for Studies on Toxic Substances (IRET), Universidad National, Heredia, Costa Rica;

    Microbiology and Environmental Toxicology, University of California, Santa Cruz, California 95064, United States;

    Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States;

    Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California 94704, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California 94704, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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