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首页> 外文期刊>Environmental Science & Technology >Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures
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Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures

机译：木质素分解真菌对抗生素药氟喹啉的生物转化及转化混合物的残留抗菌活性

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摘要

Flumequine, a fluoroquinolone antibiotic, is applied preferably in veterinary medicine, for stock breeding and treatment of aquacultures. Formation of drug resistance is a matter of general concern when antibiotics such as flumquine occur in the environment. Thus, biodegradation of flumequine in solution was investigated using five different ligninolytic fungi. Irpex lacteus, Dichomitus squalens, and Trametes versicolor proved most efficient and transformed more than 90% of flumequine within 6 or even 3 days. Panus tigrinus and Pleurotus ostreatus required up to 14 days to remove ＞90% of flumequine. Analyses of the metabolites by liquid chromatography-mass spectrometry suggest different transformation pathways for the different fungal strains. Structure proposals were elaborated for 8 metabolites. 7- Hydroxy-flumequine and flumequine ethyl ester were identified as common metabolites produced by all ligninolytic fungi. The largest variety of metabolites was formed by D. squalens. Residual antibacterial activity of the metabolite mixtures was tested using gram-positive and gram-negative bacteria. While for the less efficient P. tigrinus and P. ostreatus cultures the antibacterial activities corresponded to the residual concentrations of flumequine, a remarkable antibacterial activity remained in the D. squalens cultures although flumequine was transformed to more than 90%. Obviously, antibacterially active transformation products were formed by this fungal strain.
机译：氟喹诺酮（一种氟喹诺酮类抗生素）优选用于兽药，用于水产养殖和水产养殖。当诸如氟喹的抗生素在环境中出现时，耐药性的形成是普遍关心的问题。因此，使用五种不同的木质素分解真菌研究了氟米卡定在溶液中的生物降解。事实证明，Irpex lacteus，Dichomitus squalens和vermetcolor是最有效的，并在6甚至3天内转化了超过90％的flumequine。美洲虎和平菇需要长达14天的时间才能去除＞ 90％的氟尿嘧啶。液相色谱-质谱分析代谢物表明不同真菌菌株的转化途径不同。拟定了8种代谢物的结构建议。 7-羟基氟尿嘧啶和氟尿嘧啶乙酯被鉴定为所有木质素分解真菌产生的常见代谢产物。最大的代谢物种类是角鲨。使用革兰氏阳性和革兰氏阴性细菌测试代谢产物混合物的残留抗菌活性。尽管对于效率较低的虎疫对虾和平菇对虾，其抗菌活性对应于氟尿嘧啶的残留浓度，但尽管氟尿嘧啶已转化为90％以上，但在角鲨病菌培养物中仍保留了显着的抗菌活性。显然，该真菌菌株形成了抗菌活性转化产物。

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  • 来源
    《Environmental Science & Technology》 |2013年第24期|14128-14136|共9页
  • 作者

    Monika Cvancarova; Monika Moeder; Alena Filipova; Thorsten Reemtsma; Tomas Cajthaml;

  • 作者单位

    Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, CZ-142 20 Prague 4, Cech Republic,Institute of Environmental Studies, Faculty of Science, Charles University, Benatska 2, CZ-128 01 Prague 2, Czech Republic;

    Department of Analytical Chemistry, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, 04318 Leipzig, Germany;

    Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, CZ-142 20 Prague 4, Cech Republic;

    Department of Analytical Chemistry, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, 04318 Leipzig, Germany;

    Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, CZ-142 20 Prague 4, Cech Republic,Institute of Environmental Studies, Faculty of Science, Charles University, Benatska 2, CZ-128 01 Prague 2, Czech Republic;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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