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首页> 外文期刊>Environmental Science & Technology >Bacteriophage Inactivation by UV-A Illuminated Fullerenes: Role of Nanopartkle-Virus Association and Biological Targets
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Bacteriophage Inactivation by UV-A Illuminated Fullerenes: Role of Nanopartkle-Virus Association and Biological Targets

机译：紫外线-A富勒烯的噬菌体灭活：纳米颗粒病毒协会和生物目标的作用。

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摘要

Inactivation rates of the MS2 bacteriophage and ~1O_2, generation rates by four different photosensitized aqueous fullerene suspensions were in the same order: aqu-nC_(60) < C_(60)(OH)_6 ≈ C_(60)(OH)_(24) < C_(60)(NH_2)_6. Alterations to capsid protein secondary structures and protein oxidation were inferred by detecting changes in infrared vibrartional frequencies and carbonyl groups respectively. MS2 inactivation appears to be the result of loss of capsid structural integrity (localized deformation) and the reduced ability to eject genomic RNA into its bacterial host Evidence is also presented for possible capsid rupture in MS2 exposed to UV-A illuminated C_(60)(NH_2)_6 through TEM imagery and detection of RNA infrared fingerprints in ATR-FTIR spectra. Fullerene-virus mixtures were also directly visualized in the aqueous phase using a novel enhanced darkfield transmission optical microscope fitted with a hyperspectral imaging (HSI) spectrometer. Perturbations in intermolecular extended chains, HSI, and electrostatic interactions suggest that inactivation is a function of the relative proximity between nanopartkles and viruses and ~1O_2, generation rate. MS2 log survival ratios were linearly related to CT (product of ~1O_2 concentration C and exposure time T) demonstrating the applicability of classical Chick-Watson kinetics for all fullerenes employed in this study. Results suggest that antiviral properties of fullerenes can be increased by adjusting the type of surface functionalization and extent of cage derivatization thereby increasing the ~1O_2, generation rate and facilitating closer association with biological targets.
机译：四种不同的光敏富勒烯水悬浮液对MS2噬菌体的灭活率和〜1O_2的产生率是相同的顺序：aqu-nC_（60）

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  • 来源
    《Environmental Science & Technology》 |2012年第11期|p.5963-5970|共8页
  • 作者

    Appala Raju Badireddy; Jeffrey Farner Budarz; Shankararaman Chellam; Mark R.Wiesner;

  • 作者单位

    Department of Civil and Environmental Engineering, Duke University, Durham, North Carolina 27708, United States,Center for the Environmental Implications of NanoTechnology, Duke University, Durham, North Carolina 27708, United States;

    Department of Civil and Environmental Engineering, Duke University, Durham, North Carolina 27708, United States,Center for the Environmental Implications of NanoTechnology, Duke University, Durham, North Carolina 27708, United States;

    Departments of Civil and Environmental Engineering and Chemical and Biomolecular Engineering, University of Houston, Houston,Texas 77204, United States;

    Department of Civil and Environmental Engineering, Duke University, Durham, North Carolina 27708, United States,Center for the Environmental Implications of NanoTechnology, Duke University, Durham, North Carolina 27708, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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