...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >The Xenometabolome and Novel Contaminant Markers in Fish Exposed to a Wastewater Treatment Works Effluent
【24h】

The Xenometabolome and Novel Contaminant Markers in Fish Exposed to a Wastewater Treatment Works Effluent

机译：暴露于废水处理厂废水中的鱼类的异代谢物组和新型污染物标记

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Organisms exposed to wastewater treatment works (WwTW) effluents accumulate complex mixtures of xenobiotics but there is a scarcity of information on the nature and impacts of these chemical mixtures. We applied metabolomics techniques as a novel approach to identify xenobiotics and their metabolites (the xenometabolome) that bioconcentrate in fish exposed to a WwTW effluent. Exposed juvenile rainbow trout (Oncorhynchus mykiss) accumulated surfactants, naphthols, chlorinated xylenols, and phenoxyphenols, chlorophenes, resin acids, mefenamic acid, oxybenzone, and steroidal alkaloids in the bile or plasma, and there were perturbations in the plasma concentrations of bile acids and lipids. Exposure of adult roach (Rutilus rutilus) to 50% or 100% concentrations of the same effluent resulted in dose-dependent increases in plasma concentrations of xenometabolites as well as cyprinol sulfate and taurocnolic acid, lysophospholipids, and a decrease in sphingosine levels (a key component of cell membrane lipids). Our findings reveal the highly complex nature of xenobiotics accumulating in effluent-exposed fish, and the great potential of metabolomics for both identifying plasma marker (bio) chemicals for monitoring exposure to wastewater effluents, and for targeting studies on potential consequent impacts on fish health.
机译：暴露于废水处理厂（WwTW）废水中的生物积累了异种生物的复杂混合物，但是缺乏关于这些化学混合物的性质和影响的信息。我们将代谢组学技术作为一种新颖的方法来鉴定异生物素及其代谢物（异物代谢物），这些异物及其在暴露于WwTW废水中的鱼中生物富集。裸露的虹鳟鱼（Oncorhynchus mykiss）在胆汁或血浆中积聚了表面活性剂，萘酚，氯化二甲苯酚和苯氧酚，氯酚，树脂酸，甲芬那酸，氧苯并萘和甾体生物碱，并且血浆中的胆汁酸和脂质。成年蟑螂（Rutilus rut​​ilus）暴露于相同流出物的50％或100％浓度会导致异代谢产物以及硫酸氯氨酚和牛磺酚酸，溶血磷脂的血浆浓度呈剂量依赖性增加，鞘氨醇水平降低（关键细胞膜脂质的成分）。我们的发现揭示了在暴露于污水中的鱼中积累的异种生物的高度复杂性，以及代谢组学在识别血浆标志物（生物）化学物质以监测废水中的暴露以及针对鱼类对鱼类健康的潜在后果的针对性研究方面的巨大潜力。

著录项

  • 来源
    《Environmental Science & Technology》 |2012年第16期|p.9080-9088|共9页
  • 作者

    Raghad Al-Salhi; Alaa Abdul-Sada; Anke Lange; Charles R. Tyler; Elizabeth M. Hill;

  • 作者单位

    School of Life Sciences, University of Sussex, Brighton, U.K. BN1 9QJ;

    School of Life Sciences, University of Sussex, Brighton, U.K. BN1 9QJ;

    Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, U.K. EX4 4PS;

    Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, U.K. EX4 4PS;

    School of Life Sciences, University of Sussex, Brighton, U.K. BN1 9QJ;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号