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首页> 外文期刊>Environmental Science & Technology >Laser Ablation ICP-MS Co-Localization of Mercury and Immune Response in Fish
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Laser Ablation ICP-MS Co-Localization of Mercury and Immune Response in Fish

机译：激光烧蚀ICP-MS对鱼类中汞和免疫反应的共定位

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摘要

Mercury (Hg) contamination is a global issue with implications for both ecosystem and human health. In this study, we use a new approach to link Hg exposure to health effects in spotted gar (Lepisosteus oculatus) from Caddo Lake (TX/LA). Previous field studies have reported elevated incidences of macrophage centers in liver, kidney, and spleen offish with high concentrations of Hg. Macrophage centers are aggregates of specialized white blood cells that form as an immune response to tissue damage, and are considered a general biomarker of contaminant toxicity. We found elevated incidences of macrophage centers in liver of spotted gar and used a new technology for ecotoxtcology studies, laser ablation-inducrjvely coupled plasma-mass spectrometry (LA-ICP-MS), to colocalize aggregates and Hg deposits within the tissue architecture. We conclude that Hg compromises the health of spotted gar in our study and, perhaps, other fish exposed to elevated concentrations of Hg.
机译：汞污染是一个全球性问题，对生态系统和人类健康都有影响。在这项研究中，我们使用一种新方法将汞暴露与来自Caddo Lake（TX / LA）的斑（Lepisosteus oculatus）的健康影响联系起来。先前的野外研究已经报道，汞含量高的鱼类在肝脏，肾脏和脾脏中巨噬细胞中心的发病率升高。巨噬细胞中心是特殊的白细胞的聚集体，可形成对组织损伤的免疫反应，被认为是污染物毒性的一般生物标志。我们发现斑点雀liver肝脏中巨噬细胞中心的发生率升高，并使用一种新的生态毒理学技术（激光消融诱导耦合等离子体质谱法（LA-ICP-MS））将聚集物和汞沉积物共定位在组织结构内。我们得出的结论是，在我们的研究中，汞会损害点的健康，也许还会损害其他暴露于高浓度汞的鱼的健康。

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  • 来源
    《Environmental Science & Technology》 |2011年第20期|p.8982-8988|共7页
  • 作者

    Benjamin D. Barst; Amanda K. Gevertz; Matthew M. Chumchal; James D. Smith; Thomas R. Rainwater; Paul E. Drevnick; Karista E. Hudelson; Aaron Hart; Guido F. Verbeck; Aaron P. Roberts;

  • 作者单位

    Department of Biological Sdences & Institute of Applied Sciences, University of North Texas, 1155 Union Circle No. 310559 Denton,Terns 76203, United States;

    Department of Biological Sdences & Institute of Applied Sciences, University of North Texas, 1155 Union Circle No. 310559 Denton,Terns 76203, United States;

    Department of Biology, Texas Christian University, 2800 South University Drive, Fort Worth, Texas 76129, United States;

    Department of Biological Sdences & Institute of Applied Sciences, University of North Texas, 1155 Union Circle No. 310559 Denton,Terns 76203, United States;

    Department of Obstetrics and Gynecology, Medical University of South Carolina, Hollings Marine Laboratory, 331 Fort Johnson Road,Charleston, South Carolina 29412, United States;

    INRS-ETE, Unhrersite du Quebec, 490 de la Couronne, Quebec, QC G1K 9A9, Canada;

    Department of Biological Sdences & Institute of Applied Sciences, University of North Texas, 1155 Union Circle No. 310559 Denton,Terns 76203, United States;

    Department of Chemistry & Laboratory of Imaging Mass Spectrometry, University of North Texas, 1155 Union Circle No. 305070 Denton, Texas 76203, United States;

    Department of Chemistry & Laboratory of Imaging Mass Spectrometry, University of North Texas, 1155 Union Circle No. 305070 Denton, Texas 76203, United States;

    Department of Biological Sdences & Institute of Applied Sciences, University of North Texas, 1155 Union Circle No. 310559 Denton,Terns 76203, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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