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首页> 外文期刊>Environmental Science & Technology >Fate of the Antibiotic Sulfamethoxazole and Its Two Major Human Metabolites in a Water Sediment Test
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Fate of the Antibiotic Sulfamethoxazole and Its Two Major Human Metabolites in a Water Sediment Test

机译：水沉淀试验中抗生素磺胺甲恶唑及其两种主要人类代谢产物的命运

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摘要

Sulfonamide antibiotics are widely used in human and veterinary medicine. After their application, they are excreted in unchanged as well as in metabolized form. Due to incomplete elimination in wastewater treatment plants, they can be emitted into surface water. The environmental fate of both parent compounds and metabolites is currently unknown. The aim of this study was to determine the biodegradation potential of river sediment for the sulfonamide sulfamethoxazole (SMX) and its two major human metabolites N_4-acetyl-SMX and SMX-N_1-glucuronide using a water sediment test system. Each compound was tested in a separate series together with sterile and "water only" controls. All three compounds were efficiently removed from the test system by biodegradation in the sediment. Only for SMX-Nrglucuronide, a substantial removal in the absence of sediment was determined. Dissipation times from the aqueous phase (DT_(50)) between 8.5 and 17.2 days were measured. Sorption to sediment was of minor importance due to the slightly basic pH of the test system. By the application of a mathematical model, biodegradation half-lives in sediment between 3.3 and 25.6 h were calculated for SMX and its metabolites. The results of this study highlight the capability of native river sediment for degrading sulfonamide antibiotics, but also the potential of human metabolites to retransform into parent SMX under environmental conditions. Based on this study, it is unlikely that SMX or its metabolites will persist or accumulate in river sediments under pH conditions where sorption is of minor importance.
机译：磺胺类抗生素广泛用于人类和兽医学。施用后，它们以不变形式和代谢形式排泄。由于废水处理厂中的淘汰不彻底，它们可能被排放到地表水中。目前尚不清楚母体化合物和代谢产物的环境命运。这项研究的目的是使用水沉淀物测试系统确定河流沉淀物对磺酰胺磺胺甲基异恶唑（SMX）及其两种主要人类代谢产物N_4-乙酰-SMX和SMX-N_1-葡萄糖醛酸的生物降解潜力。将每种化合物与无菌和“纯水”对照一起在单独的系列中进行测试。通过沉积物中的生物降解将所有三种化合物有效地从测试系统中去除。仅对于SMX-葡萄糖醛酸苷，在没有沉淀物的情况下确定了基本去除。测量了水相（DT_（50））的消散时间在8.5到17.2天之间。由于测试系统的碱性较低，因此对沉淀物的吸附作用次要。通过数学模型的应用，计算出SMX及其代谢产物在沉积物中的生物降解半衰期为3.3至25.6 h。这项研究的结果突出了原生河底沉积物降解磺胺类抗生素的能力，同时也突出了人类代谢物在环境条件下重新转化为母体SMX的潜力。根据这项研究，在吸附不太重要的pH条件下，SMX或其代谢物不太可能在河流沉积物中持续存在或积累。

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  • 来源
    《Environmental Science & Technology》 |2009年第9期|3135-3141|共7页
  • 作者

    MICHAEL RADKE; CHRISTOPH LAUWIGI; GEORG HEINKELE; THOMAS E. MUERDTER; MARION LETZEL;

  • 作者单位

    Department of Hydrology, University of Bayreuth, 95440 Bayreuth, Germany;

    Department of Hydrology, University of Bayreuth, 95440 Bayreuth, Germany;

    Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany;

    Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany;

    University of Tuebingen, Germany, and Bavarian Environment Agency, Referat 76, Lazarettstr. 67, 80636 Muenchen, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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