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首页> 外文期刊>Environmental Science & Technology >Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy
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Organochlorine Compounds, Iodine Intake, and Thyroid Hormone Levels during Pregnancy

机译：怀孕期间的有机氯化合物，碘摄入和甲状腺激素水平

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摘要

The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa [n = 570), Spain. Thyroid hormones (free T4 and total T3), thyrotropin, and polychlorinated biphenyls (PCB congeners 118,138,153, and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (β-HCH), dichlorodiphenyl dichloro-ethylene (p′p′-DDE) and dichlorodiphenyl trichloroethane (p′p-DDT) were measured in serum samples collected at first trimester of pregnancy. Urinary iodine concentration (UIC) was measured and iodine intake from diet, iodized salt, and supplements were estimated from a food frequency questionnaire. Levels of HCB and PCBs congeners 180,153, and 138 were related to lower total T3 levels (adjusted coefficient (SE): -4.0(1.1), -6.1(1.6), -5.5(1.6), and 3.8(1.4), respectively) and higher free T4 levels (adjusted coefficient (SE): 0.013(0.005), 0.017(0.007), 0.016(0.007), and 0.007(0.006), respectively). These associations were homogeneous in both cohorts, especially for PCBs and total T3 (p-value forthe interaction between cohorts >0.8). Iodine intake and UIC did not affect the association between OCs and thyroid hormones. Our results indicate that exposure to OCs during pregnancy can alter TH levels.
机译：在萨瓦德尔（n = 520）和吉普斯夸（n Gipuzkoa）两项基于人群的队列研究中，大量孕妇研究了有机氯化合物（OCs）对甲状腺功能的影响以及碘摄入的潜在混杂效应。 = 570），西班牙。甲状腺激素（游离T4和总T3），促甲状腺素和多氯联苯（PCB同类物118、138、153和180），六氯苯（HCB），β-六氯环己烷（β-HCH），二氯二苯基二氯乙烯（p'p'-DDE）在怀孕前三个月的血清样本中检测了三氯乙烷和二氯二苯基三氯乙烷（p'p-DDT）。测量尿中的碘浓度（UIC），并通过食物频率调查表估算饮食，碘盐和补充品中的碘摄入量。六氯代苯和多氯联苯同类物180,153和138的水平与较低的总T3水平有关（调整系数（SE）：分别为-4.0（1.1），-6.1（1.6），-5.5（1.6）和3.8（1.4））以及更高的游离T4水平（调整系数（SE）：分别为0.013（0.005），0.017（0.007），0.016（0.007）和0.007（0.006））。这些关联在两个队列中均相同，尤其是对于PCB和总T3（队列之间的相互作用的p值> 0.8）。碘摄入和UIC不会影响OC和甲状腺激素之间的关联。我们的结果表明，怀孕期间接触OC会改变TH水平。

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  • 来源
    《Environmental Science & Technology》 |2009年第20期|7909-7915|共7页
  • 作者

    MAR ALVAREZ-PEDREROL; MONICA GUXENS; JESUS IBARLUZEA; MARISA REBAGLIATO; AGUEDA RODRIGUEZ; MERCEDES ESPADA; FERNANDO GONI; MIKEL BASTERRECHEA; JORDI SUNYER;

  • 作者单位

    Centre for Research in Environmental Epidemiology, Doctor Aiguader 88, 08006 Barcelona, Spain Municipal Institute of Medical Research (IMIM-Hospital del Mar), Doctor Aiguader 88, 08006 Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Doctor Aiguader 88, 08006 Barcelona, Spain Pompeu Fabra University, Doctor Aiguader 88, 08006 barcelona Barcelona, Spain;

    Centre for Research in Environmental Epidemiology, Doctor Aiguader 88, 08006 Barcelona, Spain Municipal Institute of Medical Research (IMIM-Hospital del Mar), Doctor Aiguader 88, 08006 Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Doctor Aiguader 88, 08006 Barcelona, Spain;

    CIBER Epidemiologia y Salud Publica (CIBERESP), Doctor Aiguader 88, 08006 Barcelona, Spain Subdireccion Salud Publica Gipuzkoa, Departamento de Sanidad del Gobierno Vasco, Avenida Navarra 4, 20013 San Sebastian, Spain;

    Miguel Hernandez University, Avenida de la Universidad, 03202 Elche, Spain;

    Hospital Pare Tauli, Pan Tauli 08208 Sabadell, Spain;

    Laboratorio Normativo de Salud Publica, Departamento de Sanidad Gobiemo Vasco, Maria Diaz de Haw 58, 48010 Bilbao, Spain;

    CIBER Epidemiologia y Salud Publica (CIBERESP), Doctor Aiguader 88, 08006 Barcelona, Spain Subdireccion Salud Publica Gipuzkoa, Departamento de Sanidad del Gobierno Vasco, Avenida Navarra 4, 20013 San Sebastian, Spain;

    CIBER Epidemiologia y Salud Publica (CIBERESP), Doctor Aiguader 88, 08006 Barcelona, Spain Subdireccion Salud Publica Gipuzkoa, Departamento de Sanidad del Gobierno Vasco, Avenida Navarra 4, 20013 San Sebastian, Spain;

    Centre for Research in Environmental Epidemiology, Doctor Aiguader 88, 08006 Barcelona, Spain Municipal Institute of Medical Research (IMIM-Hospital del Mar), Doctor Aiguader 88, 08006 Barcelona, Spain CIBER Epidemiologia y Salud Publica (CIBERESP), Doctor Aiguader 88, 08006 Barcelona, Spain Pompeu Fabra University, Doctor Aiguader 88, 08006 barcelona Barcelona, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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