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首页> 外文期刊>Environmental Science & Technology >Biotransformation Enzymes and Thyroid Axis Disruption in Juvenile Rainbow Trout (Oncorhynchus mykiss) Exposed to Hexabromocyclododecane Diastereoisomers
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Biotransformation Enzymes and Thyroid Axis Disruption in Juvenile Rainbow Trout (Oncorhynchus mykiss) Exposed to Hexabromocyclododecane Diastereoisomers

机译：暴露于六溴环十二烷非对映异构体的幼体虹鳟鱼（Oncorhynchus mykiss）中的生物转化酶和甲状腺轴破坏。

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摘要

Juvenile rainbow trout (Oncorhynchus mykiss) were fed either a reference diet or one of three diets enriched with α, β, or y diastereoisomers of hexabromocyclododecane (HBCD, C_(12)H_(18)Br_6) for 56 days. This exposure period was followed by 112 days during which all fish were fed the reference diet. Potential effects of HBCD on phase Ⅰ and Ⅱ biotransformation enzyme activities and thyroid axis disruption were examined. Disruption of the thyroid axis was most evident in the γ-HBCD exposed group, as indicated by lower circular FT4 and higher FT3 as well as an increase in thyroid epithelial cell height. However, fish fed the α-HBCD enriched diet also exhibited altered glucu-ronyltransferase activity and thyroid epithelial cell heights and the β-HBCD group had altered FT4 and FT3 and glucuronyl-transferase activity. T4ORD activity was not affected after 14 days, but was significantly lower among all HBCD exposed fish compared to the reference fish after 56 days. Results from these experiments indicate that all isomers have the potential to disrupt thyroid homeostasis.
机译：给幼年虹鳟鱼（Oncorhynchus mykiss）饲喂参考日粮或富含六溴环十二烷（HBCD，C_（12）H_（18）Br_6）的α，β或y非对映异构体的三种饮食之一。在此暴露期之后是112天，在此期间所有鱼都饲喂了参考饲料。研究了六溴环十二烷对Ⅰ和Ⅱ期生物转化酶活性和甲状腺轴破坏的潜在影响。 γ-六溴环十二烷暴露组的甲状腺轴破坏最明显，这表现为较低的圆形FT4和较高的FT3以及甲状腺上皮细胞高度的增加。然而，喂食富含α-六溴环十二烷的鱼还表现出改变的葡萄糖-丙氨酰转移酶活性和甲状腺上皮细胞高度，而β-六溴环十二烷组改变了FT4和FT3以及葡萄糖醛酸转移酶活性。 T4ORD活性在14天后没有受到影响，但是在56天后，所有HBCD接触鱼中的T4ORD活性均明显低于参考鱼。这些实验的结果表明，所有异构体均具有破坏甲状腺稳态的潜力。

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