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首页> 外文期刊>Environmental toxicology and chemistry >Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development
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Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development

机译：暴露于PBDE / OH-BDE混合物会改变幼年斑马鱼（Danio rerio）的发育

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Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g., hydroxylated BDEs [OH-BDEs]) are contaminants frequently detected together in human tissues and are structurally similar to thyroid hormones. Thyroid hormones partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window that may be vulnerable to chemicals disrupting thyroid signaling. In the present study, zebrafish were exposed to 6-OH-BDE-47 (30nM; 15g/L) alone, or to a low-dose (30g/L) or high-dose (600g/L) mixture of PentaBDEs, 6-OH-BDE-47 (0.5-6g/L), and 2,4,6-tribromophenol (5-100g/L) during juvenile development (9-23d postfertilization) and evaluated for developmental endpoints mediated by thyroid hormone signaling. Fish were sampled at 3 time points and examined for developmental and skeletal morphology, apical thyroid and skeletal gene markers, and modifications in swimming behavior (as adults). Exposure to the high-dose mixture resulted in >85% mortality within 1wk of exposure, despite being below reported acute toxicity thresholds for individual congeners. The low-dose mixture and 6-OH-BDE-47 groups exhibited reductions in body length and delayed maturation, specifically relating to swim bladder, fin, and pigmentation development. Reduced skeletal ossification was also observed in 6-OH-BDE-47-treated fish. Assessment of thyroid and osteochondral gene regulatory networks demonstrated significantly increased expression of genes that regulate skeletal development and thyroid hormones. Overall, these results indicate that exposures to PBDE/OH-BDE mixtures adversely impact zebrafish maturation during metamorphosis. Environ Toxicol Chem 2017;36:36-48. (c) 2016 SETAC
机译：多溴联苯醚（PBDEs）及其代谢产物（例如羟基化BDEs [OH-BDEs]）是在人体组织中经常一起检测到的污染物，其结构类似于甲状腺激素。甲状腺激素部分介导斑马鱼生命阶段之间的变态转变，这使其成为至关重要的发育窗口，可能容易受到化学物质破坏甲状腺信号传导的影响。在本研究中，斑马鱼单独暴露于6-OH-BDE-47（30nM; 15g / L），或暴露于低剂量（30g / L）或高剂量（600g / L）的五溴二苯醚混合物，6 -OH-BDE-47（0.5-6g / L）和2,4,6-三溴苯酚（5-100g / L）在青少年发育过程中（受精后9-23d），并评估了由甲状腺激素信号传导介导的发育终点。在三个时间点对鱼进行采样，并检查其发育和骨骼形态，顶部甲状腺和骨骼基因标记以及游泳行为的改变（成年）。尽管低于单个同类物的急性毒性阈值，暴露于高剂量混合物仍导致暴露后1周内死亡率> 85％。低剂量混合物和6-OH-BDE-47组的体长减少并延迟了成熟，特别是与游泳膀胱，鳍和色素沉着的发展有关。在6-OH-BDE-47处理的鱼中也观察到骨骼骨化的减少。对甲状腺和骨软骨基因调节网络的评估表明，调节骨骼发育和甲状腺激素的基因表达显着增加。总体而言，这些结果表明，暴露于多溴二苯醚/ OH-BDE混合物对变态期间的斑马鱼成熟有不利影响。环境毒性化学2017; 36：36-48。 （c）2016年SETAC

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