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首页> 外文期刊>Environmental toxicology and chemistry >THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON OXIDATIVE STRESS AND INNATE IMMUNE RESPONSE IN ZEBRAFISH EMBRYOS
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THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON OXIDATIVE STRESS AND INNATE IMMUNE RESPONSE IN ZEBRAFISH EMBRYOS

机译：内分泌干​​扰化学物质对斑马鱼胚胎的氧化应激和固有免疫反应的影响

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摘要

Bisphenol A (BPA) and nonylphenol (NP) are well known endocrine-disrupting chemicals (EDCs) ubiquitous in the aquatic environment and are an ecotoxicological risk for the health of aquatic organisms. Limited attention has been given to the immunotoxicity of these chemicals. The present study revealed a concentration-dependent increase of reactive oxygen species content and an induced expression of redox-sensitive transcription factors in zebrafish embryos after exposure to various concentrations of BPA, NP, and BPA/NP mixture for 4 h to 168 h postfertilization. Transcription of genes related to the immune response, including IFNy, IL1β, IL10, Mx, TNFα, CC-chemokine, and CXCL-clc, were significantly up-regulated on exposure to EDCs. A significant induction of concentrations of proinflammatory mediator, nitric oxide, accompanied by an increase in the activity of nitric oxide synthase (NOS) and an upregulation of inducible NOS gene expression, was detected in zebrafish embryos on exposures to EDCs. To elucidate the potential mechanisms by which BPA and NP activate the innate immune response, expression profiles of genes related to the Toll-like receptors (TLRs) signaling pathway were examined. Expressions of TLR3, TR1F, MyD88, SARM, IRAK4, and TRAF6 were altered on exposure to EDCs. The authors' results demonstrate that exposure to BPA and NP significantly affects the expression of genes related to immune response in zebrafish embryos following oxidative stress.
机译：双酚A（BPA）和壬基酚（NP）是在水生环境中普遍存在的破坏内分泌的化学物质（EDC），对水生生物的健康具有生态毒理学风险。这些化学品的免疫毒性受到了有限的关注。本研究揭示了在受精后4 h至168 h暴露于不同浓度的BPA，NP和BPA / NP混合物后，斑马鱼胚胎中活性氧含量的浓度依赖性增加和氧化还原敏感转录因子的诱导表达。暴露于EDC时，与免疫应答相关的基因（包括IFNγ，IL1β，IL10，Mx，TNFα，CC趋化因子和CXCL-clc）的转录显着上调。在暴露于EDCs的斑马鱼胚胎中检测到促炎性介质一氧化氮浓度的显着诱导，伴随一氧化氮合酶（NOS）活性的增加和诱导型NOS基因表达的上调。为了阐明BPA和NP激活先天免疫应答的潜在机制，研究了与Toll样受体（TLRs）信号通路相关的基因的表达谱。暴露于EDC时，TLR3，TR1F，MyD88，SARM，IRAK4和TRAF6的表达发生改变。作者的结果表明，暴露于BPA和NP会显着影响氧化应激后斑马鱼胚胎中与免疫反应相关的基因的表达。

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  • 来源
    《Environmental toxicology and chemistry》 |2013年第8期|1793-1799|共7页
  • 作者

    Hai Xu; Ming Yang; Wenhui Qiu; Chenyuan Pan; Minghong Wu;

  • 作者单位

    School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China,School of the Environment, Jiangsu University, Zhenjiang, Jiangsu, China;

    School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China;

    School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China;

    School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China;

    School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Environmental estrogen; Bisphenol A; Nonylphenol; Oxidative stress; Immune system;

    机译：环境雌激素;双酚A;壬基酚氧化应激免疫系统;

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