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首页> 外文期刊>Environmental toxicology and chemistry >EFFECTS OF THE INSECTICIDE FIPRONIL ON REPRODUCTIVE ENDOCRINOLOGY IN THE FATHEAD MINNOW
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EFFECTS OF THE INSECTICIDE FIPRONIL ON REPRODUCTIVE ENDOCRINOLOGY IN THE FATHEAD MINNOW

机译:杀虫F子对肥头草内生殖生殖的影响

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摘要

Gamma-aminobutyric acid (GABA) and GABA receptors play an important role in neuroendocrine regulation in fish. Disruption of the GABAergic system by environmental contaminants could interfere with normal regulation of the hypothalamic-pituitary-gonadal axis, leading to impaired fish reproduction. The present study used a 21-d fathead minnow (Pimephales promelas) reproduction assay to investigate the reproductive toxicity of fipronil (FIP), a broad-spectrum phenylpyrazole insecticide that acts as a noncompetitive blocker of GABA receptor-gated chloride channels. Continuous exposure up to 5 μg FIP/L had no significant effect on most of the endpoints measured, including fecundity, secondary sexual characteristics, plasma steroid and vitellogenin concentrations, ex vivo steroid production, and targeted gene expression in gonads or brain. The gonad mass, gonadosomatic index, and histological stage of the gonad were all significantly different in females exposed to 0.5 μg FIP/L compared with those exposed to 5.0 μg FIP/L; however, there were no other significant effects on these measurements in the controls or any of the other treatments in either males and females. Overall, the results do not support a hypothesized adverse outcome pathway linking FIP antagonism of the GABA receptor(s) to reproductive impairment in fish.
机译:γ-氨基丁酸(GABA)和GABA受体在鱼类神经内分泌调节中起重要作用。环境污染物破坏GABA能系统可能会干扰下丘脑-垂体-性腺轴的正常调节,从而导致鱼类繁殖受损。本研究使用21天的黑头min鱼(Pimephales promelas)繁殖试验来研究氟虫腈(FIP)的生殖毒性,氟虫腈是一种广谱的苯基吡唑杀虫剂,可作为GABA受体门控氯化物通道的非竞争性阻断剂。连续暴露至5μgFIP / L对大多数测得的终点没有显着影响,包括生育力,继发性特征,血浆类固醇和卵黄蛋白原浓度,离体类固醇生成以及性腺或大脑中的靶向基因表达。暴露于0.5μgFIP / L的雌性与暴露于5.0μgFIP / L的雌性相比,性腺的性腺质量,性腺体指数和组织学阶段均显着不同;然而,在男性或女性的对照组或任何其他治疗方法中,对这些测量值没有其他显着影响。总体而言,结果不支持将鱼类的GABA受体的FIP拮抗作用与生殖功能损害联系起来的假想的不利结果途径。

著录项

  • 来源
    《Environmental toxicology and chemistry》 |2013年第8期|1828-1834|共7页
  • 作者单位

    Ecological Exposure Research Division, National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Cincinnati, Ohio, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Ecological Exposure Research Division, National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Cincinnati, Ohio, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

    Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Pesticide; Endocrine disruption; Neurotransmitter; Fish; Fecundity;

    机译:农药;内分泌干​​扰;神经递质;鱼;生殖力;

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