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首页> 外文期刊>Environmental Science & Technology >Effects of the Feedlot Contaminant 17alpha-Trenbolone on Reproductive Endocrinology of the Fathead Minnow
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Effects of the Feedlot Contaminant 17alpha-Trenbolone on Reproductive Endocrinology of the Fathead Minnow

机译：肥育场污染物17α-群勃龙对the鱼Min鱼生殖内分泌学的影响

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摘要

Trenbolone acetate is a growth promoter widely used for beef production in the U.S.Two biologically active metabolites of the acetate,17beta-and 17alpha-trenbolone,are ligands of vertebrate androgen receptors and comparatively stable in the waste of treated animals.Both have been detected in surface water associated with beef feedlots,suggesting a potential risk to aquatic animals.In previous work we evaluated the effects of beta-trenbolone on reproductive endocrinology of the fathead minnow (Pimephales promelas)in a 21-day test.The purpose of the present study was to conduct a similar set of experiments with alpha-trenbolone which,based on binding to mammalian androgen receptors,was expected to be less potent than beta-trenbolone.Fecundity of the fish was significantly reduced by alpha-trenbolone with an EC50 (95% confidence interval)of 0.011 (0.007-0.016)mu g/L.In females,alpha-trenbolone reduced plasma vitellogenin and steroid concentrations and also induced the production of dorsal nuptial tubercles,structures normally present only in spawning males.Overall,effects of alpha-trenbolone on the reproductive system of the fish were qualitatively and quantitatively quite similarto those caused by beta-trenbolone.Part of this similarity might arise from the fact that a substantial amount of the alpha-trenbolone appeared to be converted to beta-trenbolone by the fish.Tissue concentrations of the beta-isomer were consistently similar to or greater than concentrations of alpha-trenbolone,despite the fact that no beta-trenbolone was detected in the exposure water.The present study demonstrates the importance of considering both alpha-and beta-trenbolone in assessing the potential ecological risk of androgens associated with beef feedlot discharges.
机译：群勃龙乙酸盐是一种生长促进剂，在美国被广泛用于牛肉生产。醋酸盐的两种生物活性代谢物17β-和17α-群勃龙是脊椎动物雄激素受体的配体，在被处理动物的废物中相对稳定。与牛肉饲养场相关的地表水，暗示了对水生动物的潜在风险。在先前的工作中，我们在21天的试验中评估了β-群勃龙对the鱼（Pimephales promelas）生殖内分泌学的影响。本研究的目的计划对α-群勃龙进行类似的实验，基于与哺乳动物雄激素受体的结合，预计其效力不如β-群勃龙.α-群勃龙的EC50（95％置信区间）为0.011（0.007-0.016）μg / L。在女性中，群勃龙降低血浆卵黄蛋白原和类固醇的浓度并诱导背侧产生总体上，α-群勃龙对鱼类繁殖系统的影响在质量和数量上均与β-群勃龙引起的结节相似。部分相似之处可能源于以下事实：鱼体内α-群勃龙的量似乎转化为β-群勃龙。尽管该组织中未检测到β-群勃龙，但β-异构体的组织浓度始终类似于或大于α-群勃龙的浓度。本研究表明，在评估与牛肉饲养场排放相关的雄激素的潜在生态风险时，必须同时考虑使用α-和β-群勃龙。

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  • 来源
    《Environmental Science & Technology》 |2006年第9期|p.3112-3117|共6页
  • 作者

    KATHLEEN M.JENSEN; ELIZABETH A.MAKYNEN; MICHAEL D.KAHL; GERALD T.ANKLEY;

  • 作者单位

    U.S.Environmental Protection Agency,Office of Research and Development,National Health and Environmental Effects Research Laboratory,Mid-Continent Ecology Division,6201 Congdon Boulevard,Duluth,Minnesota 55804;

    U.S.Environmental Protection Agency,Office of Research and Development,National Health and Environmental Effects Research Laboratory,Mid-Continent Ecology Division,6201 Congdon Boulevard,Duluth,Minnesota 55804;

    U.S.Environmental Protection Agency,Office of Research and Development,National Health and Environmental Effects Research Laboratory,Mid-Continent Ecology Division,6201 Congdon Boulevard,Duluth,Minnesota 55804;

    U.S.Environmental Protection Agency,Office of Research and Development,National Health and Environmental Effects Research Laboratory,Mid-Continent Ecology Division,6201 Congdon Boulevard,Duluth,Minnesota 55804;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 环境化学;
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