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首页> 外文期刊>Environmental toxicology and chemistry >COMPARISON OF THE ACUTE TOXICITIES OF NOVEL ALGICIDES, THIAZOLIDINEDIONE DERIVATIVES TD49 AND TD53, TO VARIOUS MARINE ORGANISMS
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COMPARISON OF THE ACUTE TOXICITIES OF NOVEL ALGICIDES, THIAZOLIDINEDIONE DERIVATIVES TD49 AND TD53, TO VARIOUS MARINE ORGANISMS

机译：新型杀藻剂噻唑烷二酮衍生物TD49和TD53对各种海洋生物的急性毒性比较

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摘要

Acute toxicity assessments of new algicides, thiazolidinedione derivatives TD49 and TD53, to the marine ecological system were conducted. The toxicity assessments were performed using two of the new International Organization for Standardization (ISO) standard methods employing Ulva pertusa Kjellman and three species representative of the marine ecological system, with the results compared by calculating the 50% effective concentration (EC50), 50% lethal concentration (LC50), no-observed-effect concentration (NOEC), and predicted-no-effect concentration (PNEC). In the acute toxicity assessment using the Kjellman, the EC50, NOEC, and PNEC of TD53 were 1.65 (μM, 0.08 μM, and 1.65 nM, and those of TD49 were 0.18 μM, 0.63 μM, and 0.18 nM. In the assessments using Skeletonema costatum, Daphnia magna, and Paralichthys olivaceus fry, the EC50 or LC50 of TD53 were 1.53, 0.61, and 2.14 μM, respectively, indicating that D. magna was the most sensitive. The calculated NOEC and PNEC to D. magna were 0.25 μM and 6.10 nM, respectively. The LC50s (or EC50) of TD49 for the three species were 0.34,0.68, and 0.58 μM. The NOEC and PNEC to S. costatum, the most sensitive species, were 0.2μM and 3.4 nM, respectively. The slight difference in the chemical structures of the algicides caused significantly different sensitivities and specificities in the toxicities to the employed species. The results of the toxicity assessments showed that application concentrations for algiciding of red tide blooms were higher than the corresponding PNEC values. Therefore, we suggest that a formulization study of the algicides with high specificity should be conducted to reduce the surrounding ecological toxicity.
机译：对新型杀藻剂噻唑烷二酮衍生物TD49和TD53对海洋生态系统进行了急性毒性评估。使用两种新的国际标准化组织（ISO）标准方法（使用Ulva pertusa Kjellman）和三种代表海洋生态系统的物种进行毒性评估，并通过计算50％有效浓度（EC50），50％有效成分进行比较致死浓度（LC50），无效应浓度（NOEC）和无预测浓度（PNEC）。在使用Kjellman进行的急性毒性评估中，TD53的EC50，NOEC和PNEC为1.65（μM，0.08μM和1.65 nM，而TD49的EC50，NOEC和PNEC为0.18μM，0.63μM和0.18 nM。 ostatum，Daphnia magna和Paralichthys olivaceus鱼苗的TD53的EC50或LC50分别为1.53、0.61和2.14μM，这表明D. magna最敏感，计算得出的NOEC和PNEC对D. magna的敏感度为0.25μM和。三种物种的TD49的LC50（或EC50）分别为0.34、0.68和0.58μM，对敏感性最高的链球菌的NOEC和PNEC分别为0.2μM和3.4 nM。杀藻剂的化学结构上的细微差异导致对所用物种的毒性的敏感性和特异性差异显着，毒性评估结果表明，用于赤潮水华化的施用浓度高于相应的PNEC值。暗示为了减少周围的生态毒性，应进行高特异性杀藻剂的配方研究。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第12期|p.2810-2816|共7页
  • 作者

    Seong J. Kim; Eun C. Yim; In T. Park; Si W. Kim; Hoon Cho;

  • 作者单位

    Department of Environmental Engineering, Chonnam National University, Gwangju, South Korea;

    Collaborate Course of Bioenergy and Biomaterial, Chonnam National University, Gwangju, South Korea;

    Department of Environmental Engineering, Chonnam National University, Gwangju, South Korea;

    Department of Environmental Engineering, Chosun University, Gwangju, South Korea;

    Department of Polymer Science and Engineering, Chosun University, Gwangju, South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    acute toxicity; algicide; thiazolidinedione; median lethal concentration; predicted-no-effect concentration;

    机译：急性毒性;杀藻剂噻唑烷二酮;中位致死浓度;预测无效应浓度;

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