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首页> 外文期刊>Environmental toxicology and chemistry >Validation of Dried Blood Spots for Maternal Biomonitoring of Nonessential Elements in an Artisanal and Small‐Scale Gold Mining Area of Tanzania
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Validation of Dried Blood Spots for Maternal Biomonitoring of Nonessential Elements in an Artisanal and Small‐Scale Gold Mining Area of Tanzania

机译：坦桑尼亚人工和小规模金矿区干血斑对非必需元素的母体生物监测的验证

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摘要

Biomonitoring studies of vulnerable populations in low- and middle-income countries are limited because traditional sampling methods are challenging to implement in low-resource settings. The present study examined the feasibility, precision, and accuracy of dried blood spots (DBS) for human biomonitoring of nonessential elements (cadmium [Cd], mercury [Hg], and lead [Pb]) in an area of northern Tanzania with artisanal and small-scale gold mining activities. Pregnant women (n = 44) were recruited in Geita during antenatal clinic visits, and DBS from capillary blood were collected on filter paper. As a gold-standard comparison, venous blood was sampled from the same participants and compared with the DBS. Venous blood, DBS, and quality control samples were analyzed for chemical elements by inductively coupled plasma mass spectrometry. Field blanks were very clean for most elements, generally only twice as high as corresponding laboratory filter blanks. No significant differences were found between duplicate DBS samples taken from the same participants, with near perfect intraclass correlation coefficients (0.99) for Cd, Hg, and Pb, indicating excellent reliability. Moreover, correlation was strong (r(2) 0.9) and significant (p 0.0001) between DBS and the quantitative venous blood, with regression line slopes close to 1.0 (0.847, 0.976, and 0.969 for Cd, Hg, and Pb, respectively), indicating high accuracy of the DBS method compared with the gold-standard approach. The DBS method is minimally invasive and was a feasible, precise, and accurate means of measuring exposure to Cd, Hg, and Pb in pregnant women in a low-resource setting. Environ Toxicol Chem 2019;38:1285-1293. (c) 2019 SETAC
机译：低收入和中等收入国家对脆弱人群的生物监测研究是有限的，因为传统的采样方法在资源匮乏的环境中难以实施。本研究研究了干血斑（DBS）对人体非必需元素（镉[Cd]，汞[Hg]和铅[Pb]）进行人体生物监测的可行性，精度和准确性。小型金矿开采活动。在产前门诊就诊时，在Geita招募了孕妇（n = 44），并将毛细血管血中的DBS收集在滤纸上。作为金标准比较，从同一参与者中抽取静脉血，并与DBS进行比较。通过电感耦合等离子体质谱法分析了静脉血，DBS和质量控制样品中的化学元素。现场空白对于大多数元素而言非常干净，通常仅为相应实验室过滤器空白的两倍。在相同参与者的重复DBS样本之间未发现显着差异，Cd，Hg和Pb的组内相关系数接近完美（0.99），表明具有出色的可靠性。此外，DBS与定量静脉血之间的相关性很强（r（2）> 0.9）和显着（p <0.0001），回归线斜率接近于Cd，Hg和Pb的1.0（0.847、0.976和0.969），分别表示DBS方法与金标准方法相比具有较高的准确性。 DBS方法是微创的，是一种在资源贫乏地区测量孕妇接触Cd，Hg和Pb的可行，精确和准确的方法。 Environ Toxicol Chem 2019; 38：1285-1293。 （c）2019年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2019年第6期|1285-1293|共9页
  • 作者

    Nyanza Elias C.; Dewey Deborah; Bernier Francois; Manyama Mange; Hatfield Jennifer; Martin Jonathan W.;

  • 作者单位

    Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada|Catholic Univ Hlth & Allied Sci, Sch Publ Hlth, Dept Environm Occupat Hlth & GIS, Bugando Area, Mwanza, Tanzania;

    Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada|Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada|Univ Calgary, Cumming Sch Med, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada;

    Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada|Univ Calgary, Cumming Sch Med, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada|Univ Calgary, Cumming Sch Med, Dept Med Genet, Calgary, AB, Canada;

    Weill Cornell Med Qatar, Div Med Educ, Doha, Qatar;

    Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada;

    Stockholm Univ, Dept Environm Sci & Analyt Chem, Sci Life Lab, Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Biomonitoring; Dried blood spots; Environmental exposure; Nonessential elements; Maternal; Accuracy;

    机译：生物监测;干​​血斑;环境暴露;不必要的元素;母亲;准确性;

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