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Medaka (Oryzias latipes) Multigeneration Test with Triclosan

机译：三氯生的Medaka（Oryzias latipes）多代测试

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The medaka extended one-generation reproduction test (MEOGRT) is a tier-2 study in the US Environmental Protection Agency's Endocrine Disruptor Screening Program and a level-5 study in the Organisation for Economic Co-operation and Development's conceptual framework. Integrating nonspecific apical and endocrine-specific mechanistic endpoints, results of a MEOGRT can be used, with other data, in a weight-of-evidence evaluation to establish a dose-response relationship for risk assessment and identify potential causal relationships between an endocrine mode of action and adverse effects. The MEOGRT test design was used to evaluate the multigenerational effects of the antimicrobial agent triclosan. Japanese medaka were exposed to nominal concentrations of 1.4, 2.8, 5.6, 11, and 23 mu g/L triclosan and a dilution water control starting with adult medaka (F0) through hatch in the second generation (F2). No consistent or concentration-related responses occurred in the 182-d test that suggested an endocrine-mediated effect. There were no impacts on hepatic vitellogenin, secondary sex characteristics, or sex ratio that were linked to an adverse reproductive outcome. Histopathological responses were consistent with a toxic or stress effect, particularly when considered in context with observed reductions in growth. The overall population-relevant no-observed-effect concentration was 11 mu g/L based on effects on growth. The results of the present study support a previously conducted weight-of-evidence evaluation concluding that triclosan does not act as an agonist or antagonist within estrogen, androgen, thyroid, or steroidogenic pathways. Environ Toxicol Chem 2019;38:1770-1783. (c) 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
机译：medaka扩展的第一代生殖测试（MEOGRT）是美国环境保护署的内分泌干扰物筛选计划的第二级研究，也是经济合作与发展组织概念框架的第5级研究。将非特异性心尖和内分泌特异性机制终点相结合，MEOGRT的结果可与其他数据一起用于证据权重评估中，以建立剂量-反应关系以进行风险评估，并确定内分泌方式之间的潜在因果关系。作用和不良影响。 MEOGRT测试设计用于评估抗菌剂三氯生的多代效应。从第二代（F2）的孵化开始，从成年（F0）开始，将日本高的名义浓度分别为1.4、2.8、5.6、11和23μg/ L三氯生和稀释水控制。在182-d试验中未出现一致或与浓度相关的反应，提示内分泌介导的作用。对肝卵黄蛋白原，次要性别特征或性别比的影响均与不良生殖结果无关。组织病理学反应与毒性或应激作用一致，尤其是在观察到生长减少的情况下考虑。根据对生长的影响，总的与人口有关的无观测效应浓度为11μg / L。本研究的结果支持先前进行的证据权重评估，得出结论三氯生在雌激素，雄激素，甲状腺或类固醇生成途径中不充当激动剂或拮抗剂。 Environ Toxicol Chem 2019; 38：1770-1783。 （c）2019作者。 Wiley Periodicals，Inc.代表SETAC发布的《环境毒理学和化学》。

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