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首页> 外文期刊>Environmental toxicology and chemistry >CAN THE CHOICE OF ENDPOINT LEAD TO CONTRADICTORY RESULTS OF MIXTURE-TOXICITY EXPERIMENTS?
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CAN THE CHOICE OF ENDPOINT LEAD TO CONTRADICTORY RESULTS OF MIXTURE-TOXICITY EXPERIMENTS?

机译：终点选择是否可能导致混合物毒性实验的矛盾结果？

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摘要

Theoretically, the effect of two independently acting compounds in a mixture will depend on the slope of the dose-response curves of the individual compounds if evaluated in relation to the model of concentration addition (CA). In the present study, we explored development of the shape of the dose—response relationship for four different recommended endpoints (surface area, frond number, fresh weight-specific, and dry weight-specific relative growth rates [RGR_A, RGR_F, RGR_(FW), and RGR_(DW), respectively]) and for two differently acting herbicides (metsulfuron-methyl and terbuthylazine) over time (3-15 d) on the standard test plant Lemna minor to identify endpoints and experiment times for which predictions of independent action (IA) would depart the most from those of CA. After a test time of 6 d, predictions of IA based on RGR_A and RGR_(FW) showed antagonism in relation to CA. Based on RGR_(DW), synergy was predicted, whereas IA based on RGR_F was indistinguishable from CA. To test the prediction of choice of endpoint giving different results in mixture-toxicity experiments, three endpoints and six combinations of independently acting herbicides were evaluated using isobolograms. The experiments showed that in four of six herbicide combinations, different conclusions were reached depending on endpoint. The contradictory isoboles did not follow the theory of IA and, therefore, are more likely to be related to differences in susceptibility of the physiological processes affecting each endpoint than to the shape of the dose-response curve.
机译：从理论上讲，如果相对于浓度添加（CA）模型进行评估，则混合物中两种独立起作用的化合物的效果将取决于各个化合物的剂量反应曲线的斜率。在本研究中，我们探索了四个不同推荐终点（表面积，叶数，新鲜体重特异性和干体重特异性相对增长率[RGR_A，RGR_F，RGR_（FW ）和RGR_（DW）]），并在标准测试植物Lemna minor上随时间推移（3-15 d）使用两种不同作用的除草剂（甲磺隆和丁丁嗪），以鉴定预测独立的终点和实验时间行动（IA）与CA的差异最大。经过6天的测试时间后，基于RGR_A和RGR_（FW）的IA预测显示出与CA相关的对抗性。基于RGR_（DW）可以预测协同作用，而基于RGR_F的IA与CA无法区分。为了测试混合物毒性实验中给出不同结果的终点选择的预测，使用等效线图评估了三个终点和六个独立作用的除草剂组合。实验表明，在六个除草剂组合中的四个中，根据终点得出不同的结论。相互矛盾的异构体没有遵循IA的理论，因此，更可能与影响每个终点的生理过程的药敏性差异有关，而不是与剂量反应曲线的形状有关。

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