ARYL HYDROCARBON RECEPTOR-MEDIATED AND ESTROGENIC ACTIVITIES OF OXYGENATED POLYCYCLIC AROMATIC HYDROCARBONS AND AZAARENES ORIGINALLY IDENTIFIED IN EXTRACTS OF RIVER SEDIMENTS

MIROSLAV MACHALA; MIROSLAV CIGANEK; LUDEK BLAHA

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ARYL HYDROCARBON RECEPTOR-MEDIATED AND ESTROGENIC ACTIVITIES OF OXYGENATED POLYCYCLIC AROMATIC HYDROCARBONS AND AZAARENES ORIGINALLY IDENTIFIED IN EXTRACTS OF RIVER SEDIMENTS

机译：河流沉积物提取物中最初鉴定的经氧的多环芳族碳氢化合物和氮杂芳烃的芳烃受体介导和雌激素活性

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Reproductive dysfunction in wildlife populations can be a result of environmental contaminants binding to aryl hydro- carbon receptor (AhR) or estrogenic receptors. Signaling by both types of receptors can be affected by polycyclic aromatic hydrocarbons (PAHs), which are potential endocrine disruptors. However, our knowledge regarding the effects of oxygenated (oxy)- PAHs and azaarenes on AhR-mediated and estrogenic activities is incomplete. In the present study, we have identified 9-fiuorenone, anthrone, anthraquinone, benzanthrone, benz[a]anthracene-7,12-dione, benz[c]acridine, and dibenz[a,h]acridine as prevalent oxy- PAHs and azaarenes found in river sediments.

机译：野生动物种群的生殖功能障碍可能是环境污染物与芳基碳氢化合物受体（AhR）或雌激素受体结合的结果。两种受体的信号传导都可能受到多环芳烃（PAHs）的影响，多环芳烃是潜在的内分泌干扰物。但是，我们对含氧（oxy）-PAHs和氮杂芳烃对AhR介导的和雌激素活性的影响的认识尚不完善。在本研究中，我们确定了9-氟尿酮，蒽酮，蒽醌，苯并蒽醌，苯并[a]蒽-7,12-二酮，苯并[c] ac啶和二苯并[a，h] ac啶为常见的氧基PAHs和在河流沉积物中发现了氮杂芳烃。

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来源
《Environmental toxicology and chemistry》 |2001年第12期|p.2736-2743|共8页
作者
MIROSLAV MACHALA; MIROSLAV CIGANEK; LUDEK BLAHA;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;毒物学（毒理学）;化学工业废物处理与综合利用;
关键词
Aryl hydrocarbon-mediated activity; Estrogenicity; Reporter gene bioassays;

机译：芳烃介导的活性;雌激素记者基因生物测定;

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1. Cytotoxicity and aryl hydrocarbon receptor-mediated activity of n-heterocyclic polycyclic aromatic hydrocarbons: structure-activity relationships. [J] . Sovadinova I, Blaha L, Janosek J, Environmental toxicology and chemistry . 2006,第5期

机译：n杂环多环芳烃的细胞毒性和芳烃受体介导的活性：结构-活性关系。
2. Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay [J] . Vondracek Jan, Pencikova Katerina, Neca Jiri, Environmental Pollution . 2017,第PTaA期

机译：在基于人细胞的报告基因分析中评估芳基烃受体介导的多环芳烃活性
3. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. [J] . Machala M, Vondracek J, Blaha L, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2001,第1a2期

机译：芳烃受体介导的诱变多环芳烃活性的测定采用体外报道基因检测。
4. DISTRIBUTION AND TRANSPORTATION OF POLYCYCLIC AROMATIC HYDROCARBONS IN SUSPENDED AROMATIC HYDROCARBONS IN SUSPENDED PARTICULATE MATTER AND SURFACE SEDIMENT FROM THE PEARL RIVER ESTUARY [C] . . 2001

机译：珠江口悬浮颗粒物和表层沉积物中悬浮芳香烃中多环芳烃的分布和运输
5. Polycyclic Aromatic Hydrocarbons and Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs and Oxy-PAHs) in House Dust Samples in Relation to Smoking Behavior in the Home [D] . Azure, Lorren E. 2016

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6. Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation [O] . Martina Hýžd′alová, Jakub Pivnička, Ondřej Zapletal, -1

机译：芳基烃受体依赖性代谢在多环芳烃对细胞增殖的雌激素样作用中起重要作用
7. Formation of oxygenated polycyclic aromatic hydrocarbons from polycyclic aromatic hydrocarbons during aerobic activated sludge treatment and their removal process [O] . Qiao Meng, Qi Weixiao, Liu Huijuan, 2016

机译：好氧活性污泥处理过程中由多环芳烃形成氧化多环芳烃及其去除工艺
8. Polycyclic Aromatic Hydrocarbons in Bottom Sediment and Bioavaiability in Streams in the New River Gorge National River and Gauley River National Recreation Area, West Virginia, 2002;Scientific Investigations rept [R] . Messinger, T. 2004

机译：2002年，西弗吉尼亚州新河峡谷国家河和Gauley河国家游憩区河底沉积物中的多环芳烃和生物可利用性;科学调查报告

ARYL HYDROCARBON RECEPTOR-MEDIATED AND ESTROGENIC ACTIVITIES OF OXYGENATED POLYCYCLIC AROMATIC HYDROCARBONS AND AZAARENES ORIGINALLY IDENTIFIED IN EXTRACTS OF RIVER SEDIMENTS

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