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首页> 外文期刊>Environmental toxicology and chemistry >Application of an Effects‐Based Monitoring Strategy to Assess the Impact of Contaminants on Fish Health in an Urbanized Watershed
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Application of an Effects‐Based Monitoring Strategy to Assess the Impact of Contaminants on Fish Health in an Urbanized Watershed

机译：基于效果的监测策略在城市分水岭中评估污染物对鱼类健康影响的影响

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Effects-based monitoring frameworks that combine the use of analytical chemistry with in vitro cell bioassays, as well as in vivo whole organism tests offer an integrative approach to broadly screen for chemical contaminants and link their presence with adverse effects on aquatic organisms. California (USA) is currently evaluating the use of such a framework to assess the impact of contaminants of emerging concern (CECs) on biota in urbanized rivers and other waterbodies. In the present study, the occurrence and effects of contaminants found in the Los Angeles River (Los Angeles County, CA, USA) were examined using analytical chemistry and in vitro and in vivo bioassays. Male fathead minnows were deployed in field-based exposure units and exposed to river water for 21 d. The 2 field sites (above Bull Creek [BLC] and below Glendale Water Reclamation Plant [GWR]) were selected based on their unique characteristics and different contaminant discharge sources. In addition, 2 control units (filtered city water and estrone-spiked water) were added to the experimental design. Chemical analyses revealed differences in abundance of CECs between the 2 field sites and the controls, with GWR having the highest number and concentrations of CECs and metals. Cell bioassays screening for estrogenic, glucocorticoid, progestin, and dioxin-like activities were near or below detection limits in all river water samples, indicating a low potential for endocrine-related toxicity and tissue damage. Cell bioassay results were corroborated by the in vivo analyses. Field-exposed fish exhibited no changes in plasma hormones (e.g., estradiol), vitellogenin, or gonad maturation, but gene biomarkers of chemical exposure (cytochrome p450 1A and metallothionein) were significantly elevated, confirming exposure of the fish to complex chemical mixtures. The results demonstrate the value of a tiered monitoring approach to assess the sublethal effects of chemical mixtures on aquatic life. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC
机译：基于效果的监测框架，即结合使用分析化学与体外细胞生物测定的使用，以及体内整个生物测试提供了一种综合的方法，以广泛地筛选化学污染物，并将其存在与水生生物的不利影响。加州（美国）目前正在评估这样一个框架的使用，以评估新兴问题（CEC）污染物对Biota在城市化河流和其他Waterbodies中的影响。在本研究中，使用分析化学和体外和体内生物测量，检查洛杉矶河（洛杉矶县，CA，USA）中发现的污染物的发生和影响。雄性迷你矿鱼于基于现场的曝光装置部署并暴露于河水21天。根据其独特的特性和不同的污染物排放来源选择2个现场网站（高于公牛溪[BLC]和GWR]）和下面的Glendale水回收厂[GWR]）。此外，还加入了2个控制单元（过滤城市水和股票水）以进行实验设计。化学分析揭示了2场网站和对照之间的丰度的差异，GWR具有最高数量和CEC和金属浓度。用于雌激素，糖皮质激素，孕激素和二恶英样活动的细胞生物测定筛选在所有河水样本中接近或低于检测限，表明内分泌相关毒性和组织损伤的低潜力。细胞生物测定结果通过体内分析进行了证实。现场暴露的鱼类表现出血浆激素（例如，雌二醇），Vitellogenin或Gonad成熟的任何变化，但化学暴露的基因生物标志物（细胞色素P450 1A和Metallothionein）明显升高，确认鱼暴露于复杂的化学混合物。结果证明了评估化学混合物对水生寿命的核心作用的分层监测方法的价值。环境毒素化学2020; 00：1-11。 （c）2020 Setac

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