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首页> 外文期刊>Environmental toxicology and chemistry >A Critical Review of the Environmental Occurrence and Potential Effects in Aquatic Vertebrates of the Potent Androgen Receptor Agonist 17β-Trenbolone
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A Critical Review of the Environmental Occurrence and Potential Effects in Aquatic Vertebrates of the Potent Androgen Receptor Agonist 17β-Trenbolone

机译：对有效雄激素受体激动剂17β-群勃龙水生脊椎动物中环境发生和潜在影响的评论。

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Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17-trenbolone, have been detected at low nanograms per liter concentrations in surface waters associated with animal feedlots. The 17-trenbolone isomer can affect androgen receptor signaling pathways in various vertebrate species at comparatively low concentrations/doses. The present article provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of 17-trenbolone, with an emphasis on potential risks to aquatic animals. In vitro studies indicate that, although 17-trenbolone can activate several nuclear hormone receptors, its highest affinity is for the androgen receptor in all vertebrate taxa examined, including fish. Exposure of fish to nanograms per liter water concentrations of 17-trenbolone can cause changes in endocrine function in the short term, and adverse apical effects in longer exposures during development and reproduction. Impacts on endocrine function typically are indicative of inappropriate androgen receptor signaling, such as changes in sex steroid metabolism, impacts on gonadal stage, and masculinization of females. Exposure of fish to 17-trenbolone during sexual differentiation in early development can greatly skew sex ratios, whereas adult exposures can adversely impact fertility and fecundity. To fully assess ecosystem-level risks, additional research is warranted to address uncertainties as to the degree/breadth of environmental exposures and potential population-level effects of 17-trenbolone in sensitive species. Environ Toxicol Chem 2018;37:2064-2078. Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
机译：群勃龙乙酸酯由于对牲畜具有合意的合成代谢作用而在世界某些地区被广泛使用。在与动物饲养场相关的地表水中，乙酸的几种代谢物（包括17-群勃龙）的浓度为每升低纳克。 17-群勃龙酮异构体可以以相对较低的浓度/剂量影响各种脊椎动物物种中的雄激素受体信号传导途径。本文提供了有关17-群勃龙的暴露及其生物学效应的现有文献的全面综述和综述，重点是对水生动物的潜在风险。体外研究表明，尽管17-群勃龙可以激活多种核激素受体，但在包括鱼在内的所有脊椎动物类群中，其最高亲和力是对雄激素受体的。将鱼类暴露于每升水中17-群勃龙浓度为纳克的水平，在短期内可引起内分泌功能的变化，并在发育和繁殖期间长时间暴露于有害的根尖作用。对内分泌功能的影响通常表示不适当的雄激素受体信号传导，例如性类固醇代谢的变化，对性腺阶段的影响和女性的男性化。在早期发育过程中，在性别分化期间将鱼暴露于17-群勃龙可能会严重影响性别比例，而成年暴露则可能对生育力和繁殖力产生不利影响。为了全面评估生态系统级别的风险，有必要进行更多的研究来解决有关环境暴露的程度/广度以及敏感物种中17-群勃龙的潜在种群级别影响的不确定性。 Environ Toxicol Chem 2018; 37：2064-2078。代表SETAC发布了2018年Wiley Periodicals Inc ..本文是美国政府的工作，因此，它属于美国的公共领域。

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