Inhibition of reactivation in latently infecting pseudorabies virus by RNA interference

Seiichi TANAKA; Kazuaki MANNEN

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Inhibition of reactivation in latently infecting pseudorabies virus by RNA interference

机译：RNA干扰抑制潜伏感染假狂犬病毒的再激活

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In this study, we analyzed the kinetics of UL41 that had RNase activity and the efffect of siRNA inhibition in the reactivation of latently infected pseudorabies virus (PRV) by using murine model. At 1 and 3 hours after stimulating with Acetylcholine, UL41 was translated in the trigeminal ganglia of latently infected mouse. The virus reactivation from the trigeminal ganglia cultured with siRNA against UL41 was reduced more than the culture without siRNA. The latently infected mice administrated siRNA intracerebraly excreted reactivated virus less than the mice not administrated. These results show the RNA degradation in PRV reactivation was caused by the RNase activity of UL41 and there is possibility the latent PRV reactivation is able to be controled by inhibiting UL41.

机译：在这项研究中，我们通过使用鼠模型分析了具有RNase活性的UL41的动力学以及siRNA抑制在潜伏感染的伪狂犬病病毒（PRV）的激活中的作用。在用乙酰胆碱刺激后1和3小时，UL41在潜伏感染小鼠的三叉神经节中被翻译。与没有siRNA的培养相比，用siRNA培养的针对UL41的三叉神经节的病毒再激活减少的更多。与未给药的小鼠相比，给予siRNA脑内分泌的siRNA潜伏感染的小鼠重新激活的病毒要少。这些结果表明PRV再激活中的RNA降解是由UL41的RNase活性引起的，并且有可能通过抑制UL41来控制潜在的PRV再激活。

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来源
《Experimental Animals》 |2008年第3supa期|p.65|共1页
作者
Seiichi TANAKA; Kazuaki MANNEN;
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作者单位

Institute of Scientific Research, Oita University;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类动物学;
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专利

1. Herpes simplex virus type 1 ICP-0 induces reactivation of pseudorabies virus from latently infected trigeminal ganglia explant cultures. [J] . Smith TA, Cheung AK Archives of virology . 1998,第3期

机译：1型单纯疱疹病毒ICP-0可以从潜伏感染的三叉神经节外植体培养物中重新激活假狂犬病病毒。
2. Analysis of the Mechanism of Reactivation of Latently Infecting Pseudorabies Virus by Acetylcholine [J] . Tanaka Seiichi, Mannen Kazuaki The Journal of Veterinary Medical Science . 2014,第5期

机译：乙酰胆碱激活潜伏感染伪狂犬病病毒的机制分析
3. Analysis of the Mechanism of Reactivation of Latently Infecting Pseudorabies Virus by Acetylcholine [J] . Kazuaki MANNEN, Seiichi TANAKA The Journal of Veterinary Medical Science . 2014,第5期

机译：乙酰胆碱激活潜伏感染伪狂犬病病毒的机制分析
4. REDUCTION OF WILD-TYPE PSEUDORABIES VIRUS LATENT INFECTION FOLLOWING INTRANASAL VACCINATION AT BIRTH OF PASSIVELY IMMUNE PIGS [C] . MB McCaw, F Osorio, J Wheeler, Congress of the International Pig Veterinary Society . 2002

机译：在被动免疫猪出生时肿瘤疫苗接种后伴野生型伪病毒潜伏感染
5. A role for the Herpesvirus saimiri U RNAs in latently infected T cells. [D] . Cook, Heidi L. 2005

机译：疱疹病毒Saimiri U RNA在潜在感染的T细胞中的作用。
6. Inhibition of Replication of Reactivated Human Immunodeficiency Virus Type 1 (HIV-1) in Latently Infected U1 Cells Transduced with an HIV-1 Long Terminal Repeat-Driven PKR cDNA Construct [O] . Nicholas F. Muto, Camille Martinand-Mari, Martin E. Adelson, 1999

机译：在潜在感染的U1细胞中感染HIV-1长末端重复驱动的PKR cDNA转导的复制的激活的人类免疫缺陷病毒1型（HIV-1）的复制的抑制作用。
7. Analysis of the Mechanism of Reactivation of Latently Infecting Pseudorabies Virus by Acetylcholine [O] . Seiichi TANAKA, Kazuaki MANNEN 2014

机译：乙酰胆碱延伸伪症病毒重新激活机制分析
8. Inhibition of RNA Viruses In Vitro and in Rift Valley Fever-Infected Mice by Didemnins A and B. [R] . Canonico, P. G., Pannier, W. L., Huggins, J. W., 1982

机译：Didemnins a和B对体外和裂谷热感染小鼠体内RNa病毒的抑制作用

Inhibition of reactivation in latently infecting pseudorabies virus by RNA interference

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